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Fig. 4 | BMC Cancer

Fig. 4

From: Macrophage infiltration in 3D cancer spheroids to recapitulate the TME and unveil interactions within cancer cells and macrophages to modulate chemotherapeutic drug efficacy

Fig. 4

A Graph representing DCFHDA-green mediated reactive oxygen species (ROS) mean florescence intensity in single cell suspension of CAL33 spheroids with and without macrophages from day 1 to day 11, B Graph representing titanium(IV) sulfate (TiSO4) mediated hydrogen peroxide (H2O2) release in conditioned media collected from CAL33 spheroids with and without macrophages from day 1 to day 11, C Graph representing Griess/nitrite test results for nitric oxide (NO) release in conditioned media collected from CAL33 spheroids with and without macrophages from day 1 to day 11. The measurements were performed for all the conditions in triplicates (n = 3, with 3 spheroids single cell suspension in each condition). Statistical significance was analyzed using two-way ANOVA with Sidak's multiple comparisons test and the p-values obtained are indicated (ns p = 0.6271, **** p =  < 0.0001, ** p = 0.0028, **** p =  < 0.0001)

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BMC Cancer

ISSN: 1471-2407

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