Table 2 Any Grade And Grade ≥ 3 Adverse Events Reported In The Included Studies In This Meta-Analysis

General disorders and administration site conditions

Fatigue

414 (58.06)

7 (0.98)

386 (53.76)

3 (0.42)

Anemia

340 (47.69)

104 (14.59)

339 (47.21)

82 (11.42)

Infusion related reaction

61 (8.55)

8 (1.12)

51 (7.10)

10 (1.39)

Decreased appetite

52 (7.29)

0

43 (5.99)

0

Weight loss

35 (4.91)

2 (0.28)

27 (3.76)

3 (0.42)

Fever

14 (1.96)

0

9 (1.25)

1 (0.14)

Generalized Pain

3 (0.42)

0

5 (0.70)

1 (0.14)

Nervous system disorders

Peripheral sensory neuropathy

344 (48.25)

9 (1.26)

346 (48.19)

6 (0.84)

Paresthesia

17 (2.38)

2 (0.28)

26 (3.62)

1 (0.14)

Stroke

1 (0.14)

1 (0.14)

1 (0.14)

1 (0.14)

Vasovagal reaction

1 (0.14)

1 (0.14)

0

0

Cardiovascular system disorders

Hypertension

71 (9.96)

27 (3.79)

61 (8.50)

11 (1.53)

Supraventricular tachycardia

0

0

1 (0.14)

1 (0.14)

Cardiac disorders (other)

1 (0.14)

1 (0.14)

0

0

Vascular disorders

Pulmonary embolism

6 (0.84)

6 (0.84)

5 (0.70)

5 (0.70)

Thromboembolic event

6 (0.84)

1 (0.14)

2 (0.28)

0

Hot flashes

1 (0.14)

1 (0.14)

2 (0.28)

0

Respiratory, thoracic and mediastinal disorders

Dyspnea

134 (18.79)

14 (1.96)

124 (17.27)

2 (0.28)

Pneumonitis

5 (0.70)

2 (0.28)

3 (0.42)

1 (0.14)

Gastrointestinal disorders

Nausea

330 (46.28)

7 (0.98)

294 (40.95)

5 (0.70)

Constipation

266 (37.31)

5 (0.70)

246 (34.26)

3 (0.42)

Diarrhea

234 (32.82)

12 (1.68)

207 (28.83)

4 (0.56)

Vomiting

86 (12.06)

5 (0.70)

54 (7.52)

5 (0.70)

Colitis

11 (1.54)

0

4 (0.56)

1 (0.14)

Pyrexia

6 (0.84)

6 (0.84)

2 (0.28)

2 (0.28)

Abdominal pain

7 (0.98)

2 (0.28)

3 (0.42)

0

Pancreatitis

1 (0.14)

0

4 (0.56)

0

Mucositis oral

2 (0.28)

0

3 (0.42)

0

Ascites

1 (0.14)

1 (0.14)

0

0

Hepatic Failure

1 (0.14)

1 (0.14)

0

0

Colonic obstruction

0

0

1 (0.14)

1 (0.14)

Renal and urinary disorders

Urinary tract infection

4 (0.56)

4 (0.56)

7 (0.97)

5 (0.70)

Acute Kidney Injury

7 (0.98)

7 (0.98)

3 (0.42)

3 (0.42)

Urinary tract obstruction

1 (0.14)

1 (0.14)

0

0

Bladder infecction

1 (0.14)

0

1 (0.14)

0

Skin and subcutaneous tissue disorders

Alopecia

145 (20.34)

0

149 (20.75)

0

Rash

125 (17.53)

7 (0.98)

77 (10.72)

4 (0.56)

Pruritus

5 (0.70)

1 (0.14)

2 (0.28)

0

Erythema multiforme

2 (0.28)

1 (0.14)

1 (0.14)

0

Musculoskeletal and connective tissue disorders

Arthralgia

191 (26.79)

3 (0.42)

203 (28.27)

3 (0.42)

Myalgia

137 (19.21)

2 (0.28)

133 (18.52)

5 (0.70)

Asthenia

2 (0.28)

2 (0.28)

6 (0.84)

6 (0.84)

Muscular weakness

5 (0.70)

5 (0.70)

1 (0.14)

1 (0.14)

Myositis

2 (0.28)

0

1 (0.14)

1 (0.14)

Bone pain

1 (0.14)

0

3 (0.42)

0

Musculoskeletal and connective tissue disorders (other)

1 (0.14)

1 (0.14)

0

0

Endocrine system disorders

Hypothyroidism

112 (15.71)

27 (3.78)

79 (11.00)

7 (0.97)

Hyperthyroidism

26 (3.65)

0

11 (1.53)

0

Adrenal Insuffiency

4 (0.56)

0

1 (0.14)

0

Hypophysitis

2 (0.28)

2 (0.28)

0

0

Metabolism and nutrition disorders

Hypomagnesemia

52 (7.29)

0

70 (9.75)

0

Hypokalemia

12 (1.68)

0

9 (1.25)

0

Hyperglycaemia

5 (0.70)

2 (0.28)

2 (0.28)

0

Anorexia

2 (0.28)

1 (0.14)

5 (0.70)

0

Hypertriglyceridemia

4 (0.56)

1 (0.14)

0

0

Hypercalcemia

2 (0.28)

0

2 (0.28)

0

Glucose Intolerance

2 (0.28)

0

0

0

Reproductive system and breast disorders

Uterine hemorrhage

4 (0.56)

0

1 (0.14)

1 (0.14)

Pelvic pain

1 (0.14)

1 (0.14)

2 (0.28)

0

Vaginal hemorrhage

2 (0.28)

1 (0.14)

0

0

Reproductive system and breast disorders (other)

1 (0.14)

1 (0.14)

0

0

Blood and lymphatic system disorders

Neutropenia or Neutrophil count decreased

154 (21.60)

110 (15.43)

172 (23.96)

104 (14.48)

Thrombocytopenia

137 (19.21)

20 (2.80)

106 (14.76)

9 (1.25)

White blood cell decreased

36 (5.05)

23 (3.23)

30 (4.17)

21 (2.92)

Alanine aminotransferase increased

22 (3.08)

1 (0.14)

4 (0.56)

0

Platelet count decreased

16 (2.24)

5 (0.70)

17 (2.37)

3 (0.42)

Alkaline phosphatase increased

6 (0.84)

3 (0.42)

1 (0.14)

0

Aspartate aminotransferase increased

7 (0.98)

1 (0.14)

2 (0.28)

0

Creatinine increased

4 (0.56)

0

4 (0.56)

1 (0.14)

Gamma-glutamyl transferase increased

5 (0.70)

1 (0.14)

2 (0.28)

0

Blood bilirubin increased

2 (0.28)

1 (0.14)

0

0

Leukocytosis

0

0

1 (0.14)

1 (0.14)

Immune system disorders

Allergic reaction

8 (1.12)

4 (0.56)

6 (0.84)

1 (0.14)

Immune system disorders (other)

1 (0.14)

1 (0.14)

0

0

Infections and infestations

Tooth infection

1 (0.14)

1 (0.14)

0

0

Wound complication

1 (0.14)

1 (0.14)

0

0

Infections and infestations (other)

5 (0.70)

2 (0.28)

2 (0.28)

0