Table 5 mRNA correlation between LAG3 and gene markers of TIICs in MPM from TCGA

Immune checkpoint

CD274

0.3971

0.0001

PDCD1

0.5508

 < 0.0001

CTLA4

0.5783

 < 0.0001

Macrophages

CD68

0.5062

 < 0.0001

M1-type (classically activated) macrophages

NOS2

-0.0912

0.4007

M2-type (alternatively activated) macrophages

ARG1

0.1393

0.1982

MRC1

0.0992

0.3604

Tumor-associated macrophages

HLA-G

0.4517

 < 0.0001

CD80

0.5561

 < 0.0001

CD86

0.4983

 < 0.0001

Monocytes

CD14

0.303

0.0043

Natural killer cells

XCL1

0.4609

 < 0.0001

KIR3DL1

0.2702

0.0114

CD7

0.3896

0.0002

Neutrophils

MPO

0.3458

0.001

Dendritic cells

CD1C

-0.1125

0.2997

B cells

CD19

0.1919

0.0749

CD38

0.6018

 < 0.0001

CD8 + T cells

CD8A

0.5744

 < 0.0001

CD8B

0.5594

 < 0.0001

Follicular helper T cells

CXCR5

0.3631

0.0005

ICOS

0.603

 < 0.0001

BCL6

-0.2906

0.0063

T helper-1 cells

IL12RB2

0.3758

0.0003

T helper-2 cells

CCR3

0.1533

0.1563

STAT6

0.0411

0.7055

GATA3

0.2013

0.0615

T helper-9 cells

TGFBR2

-0.1495

0.1668