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Table 3 The association between LAG3 expression and clinical variables

From: LAG3 is an independent prognostic biomarker and potential target for immune checkpoint inhibitors in malignant pleural mesothelioma: a retrospective study

 

mRNA (N = 86)

 

IHC (N = 37)

 

Characteristics

95% CI

P value

95% CI

P value

Age

-4.204–4.421

0.9602

-13.52–-2.253

0.0074

Sex

 Male vs Female

-1.302–0.5980

0.4633

-0.5928–0.2928

0.4962

Stage

 II vs. I

-1.557–0.8468

0.5476

-0.8717–0.0308

0.0659

 III vs. I

-1.424–0.8595

0.6220

-0.8338–-0.0753

0.0212

 IV vs. I

-1.254–2.016

0.6347

-0.7821–0.2626

0.3075

Histology

 Epithelioid vs Biphasic + Sarcomatoid

-0.7542–0.9437

0.8248

-0.5368–0.1214

0.2083

 Smoking history

 Never vs Ex + Current

  

-0.5036–0.2203

0.4325

Respiratory function test

 %VC ≥ 80 vs. %VC < 80

  

-0.1849–0.5182

0.3407

  1. IHC Immunohistochemistry, VC Vital capacity
  2. mRNA expression is from TCGA (The Cancer Genome Atlas),
  3. and immunohistochemical expression is from our cohort