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Table 2 Patients’ characteristics and results of LAG3 expression

From: LAG3 is an independent prognostic biomarker and potential target for immune checkpoint inhibitors in malignant pleural mesothelioma: a retrospective study

 

mRNA (N = 86)

IHC (N = 37)

Characteristics

Values

Values

Age, Mean

63.1

66.3

Sex

 Male

70 (81.6%)

32 (86.5%)

 Female

16 (18.4%)

5 (13.5%)

Stage

 I

10 (11.5%)

11 (29.7%)

 II

16 (18.4%)

8 (21.6%)

 III

44 (51.7%)

11 (29.7%)

 IV

16 (18.4%)

7 (18.9%)

Histology

 Epithelioid

57 (65.5%)

26 (70.3%)

 Biphasic

23 (31.0%)

5 (13.5%)

 Sarcomatoid

1 (2.3%)

5 (13.5%)

 Unknown

5 (5.7%)

1 (2.7%)

LAG3

 High (mRNA), Positive (IHC)

34 (39.5%)

10 (27.0%)

 Low (mRNA), Negative (IHC)

52 (60.5%)

27 (73.0%)

Smoking history

 Never

 

9 (24.3%)

 Ex + Current

 

28 (75.7%)

Respiratory function test

 %VC ≥ 80

 

12 (32.4%)

 %VC < 80

 

19 (51.4%)

 Unknown

 

6 (16.2%)

  1. IHC Immunohistochemistry, VC Vital capacity
  2. mRNA expression is from TCGA (The Cancer Genome Atlas),
  3. and immunohistochemical expression is from our cohort