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Table 1 Diagnostic efficacy of GLS1, AFP, GPC3 and their combination for diagnosing HCC

From: Kidney-type glutaminase is a biomarker for the diagnosis and prognosis of hepatocellular carcinoma: a prospective study

variable

Sen

Spe

PPV

NPV

Youden index

GPC3

0.789

0.886

0.986

0.296

0.675

AFP

0.310

0.991

0.997

0.126

0.301

GLS1

0.746

0.842

0.979

0.249

0.588

GPC3 + GLS1

0.833

0.886

0.987

0.347

0.719

AFP + GLS1

0.789

0.833

0.979

0.284

0.623

GPC3 + GLS1 + AFP

0.846

0.886

0.987

0.366

0.732

  1. Abbreviations: GPC3, glypican3; GLS1, Kidney-type glutaminase; AFP, alpha-fetoprotein; Sen, sensitivity; Spe, specificity; NPV, negative predictive value; PPV, positive predictive value
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BMC Cancer

ISSN: 1471-2407

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