Table 3 Threshold scores in 8 threshold technique/TTO/TTM studies
From: Differences between physician and patient preferences for cancer treatments: a systematic review
Preferences measurement question | Objective point | Threshold scores | Consistency (P-value) | ||
|---|---|---|---|---|---|
Physicians | Patients | ||||
Post, C. C. B. | 1 Accept chemoradiotherapy VS. radiotherapy alone | 5Y-survival rate (over baseline rate) | 5% | 10% | 0.024 |
Kennedy, E. D. | 1 Accept nonoperative management VS. abdominal perineal resection | 5Y-local regrowth rate | 5.0% | 20.0% | NA |
2 Accept nonoperative management VS. abdominal perineal resection | 5Y-survival rate | 75.0% | 60.0% | NA | |
Kahler, K. C. | 1 Accept interferon alfa-2a and 2b (IFN) with mild-to-moderate side effects VS. without any IFN treatment | 5Y-DFS rate | 42.3% | 59.6% | < 0.001 |
2 Accept interferon alfa-2a and 2b (IFN) with severe side effects VS. without any IFN treatment | 53.6% | 69.8% | < 0.001 | ||
3 Accept mild-to-moderate side effects for adjuvant IFN | Risk of recurrence | 46.0% | 65.0% | 0.001 | |
Lee, J. Y. | 1 Accept no lymphadenectomy VS. routine lymphadenectomy | Risk of recurrence | 2.75% | 3% | 0.620 |
Blinman, P. | 1 Accept the addition of adjuvant chemotherapy to pelvic radiotherapy VS. no treatment (5 life years) | Life years | 6 years | 6 years | 0.400 |
2 Accept the addition of adjuvant chemotherapy to pelvic radiotherapy VS. no treatment (8 life years) | 9 years | 9 years | |||
3 Accept the addition of adjuvant chemotherapy to pelvic radiotherapy VS. no treatment (50% survival rate at 5 years) | Survival rate | 57% | 55% | 0.030 | |
4 Accept the addition of adjuvant chemotherapy to pelvic radiotherapy VS. no treatment (65% survival rate at 5 years) | 75% | 69% | |||
Blinman, P. | 1 Accept the adjuvant chemotherapy VS. no treatment (3 life years) | Life years | 3.9 years | 3.9 years | NA |
2 Accept the adjuvant chemotherapy VS. no treatment (5 life years) | 5.9 years | 5.9 years | |||
3 Accept the adjuvant chemotherapy VS. no treatment (50% survival rate at 5 years) | Survival rate | 55% | 55% | ||
4 Accept the adjuvant chemotherapy VS. no treatment (65% survival rate at 5 years) | 70% | 70% | |||
Kunneman, M. | 1 Accept surgery only VS. vaginal brachy therapy and surgery | 5Y-recurrence rate | 10% | 2% | < 0.001 |
Solomon, M. J. (TTO Part) | 1 Accept laparoscopic surgery VS. open surgery | Mortality risk | 3.20% | 5% | NA |
2 Accept local resection VS. colostomy | 13.40% | 17.20% | |||
3 Accept surgery alone VS. surgery and chemotherapy | 12.70% | 21.40% | |||
4 Accept chemoradiotherapy and no surgery VS. surgery and colostomy | 16.65% | 6.10% | |||