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Table 3 First line treatment

From: Stem cell collection after lenalidomide, bortezomib and dexamethasone plus elotuzumab or isatuximab in newly diagnosed multiple myeloma patients: a single centre experience from the GMMG-HD6 and -HD7 trials

Variable

Overall cohort

RVd (six 21-day cycles)

isatuximab-RVd (six 21-day cycles)

RVd (four 21-day cycles)

elotuzumab-RVd (four 21-day cycles)

p value

n

%

n

%

n

%

n

%

n

%

Patient number

179

100

44

100

35

100

51

100

49

100

/

Remission post induction

          

0.006a

 CR and nCR

52

29

22

50

12

34

10

20

8

16

 VGPR

76

42

10

23

16

46

25

49

25

51

 PR or worse

51

29

12

27

7

20

16

32

16

33

Median number of induction cycles (range)

4

(4–6)

6

(4–6)

6

(4–6)

4

(3–4)

4

(3–4)

/

  1. aCR + nCR versus VGPR versus PR or worse
  2. ABSCT Autologous blood stem cell transplantation, CR Complete response, HDCT High-dose chemotherapy, MR Minimal response, NA Not available, n.a. Not applicable, nCR Near complete response, PBSC Peripheral blood stem cells, PD Progressive disease, PR Partial response, RVd Lenalidomide, bortezomib, dexamethasone, SD Stable disease, VGPR Very good partial response, VCD Bortezomib, cyclophosphamide, dexamethasone