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Table 2 Treatment responses of whole group and different subgroups

From: Efficacy and safety of dacomitinib in treatment-naïve patients with advanced NSCLC harboring uncommon EGFR mutation: an ambispective cohort study

 

Objective response

Disease control

Median PFS

No. (%)

95%CI

No. (%)

95%CI

Months (95% CI)

Whole group (n = 16)

11 (68.8)

41.3 to 89.0

15 (93.8)

69.8 to 99.8

14.0 (4.3 to 23.7)

Major EGFR mutation

     

 G719X (n = 9)

6 (66.7)

29.9 to 92.5

8 (88.9)

51.8 to 99.7

14.0 (4.2 to 23.8)

 L861Q (n = 4)

2 (50.0)

6.8 to 93.2

4 (100.0)

39.8 to 100.0

6.5 (0 to 20.7)

Evaluable Brain metastasis (n = 6a)

5 (83.3)

35.9 to 99.6

6 (100.0)

54.1 to 100.0

9.0 (6.9 to 11.1)

  1. Abbreviations: CI Confidence interval, PFS Progression-free survival, EGFR Epidermal growth factor receptor
  2. aThe ORR and DCR for these patients were intracranial ORR and DCR