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Fig. 6 | BMC Cancer

Fig. 6

From: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells

Fig. 6

LRPPRC knockdown disturb mitochondrial membrane potential and decreased mitochondrial function. After LRPPRC knockdown in PCs and CSCs of MG63 or U2OS, under hypoxia condition, mitochondrial membrane potential was measured by JC-1 staining and analyzed by performing flow cytometry (A). (B) LDH leakage was measured by detecting LDH content in supernatant. *P<0.05, vs. shScram group. (C) total ATP synthesis was measured. *P<0.05, vs. MG63-shScram group; #P<0.05, vs. U2OS-shScram group. (D) mitochondrial DNA content was measured by performing quantitative PCR. *P<0.05, vs. MG63-shScram group; #P<0.05, vs. U2OS-shScram group

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BMC Cancer

ISSN: 1471-2407

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