Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines

Table 3 Correlation of immunosuppressive markers with cholinergic markers in CRC patients

		PD-L1	PD-L2	M3R	α7nAChR	ChAT
PD-L1	Pearson Correlation	1	0.351**	0.562**	0.236*	0.324**
	Sig. (2-tailed)		0.001	0.000	0.025	0.002
	N	91	91	91	91	91
PD-L2	Pearson Correlation	0.351^**	1	0.153	0.561^**	0.370^**
	Sig. (2-tailed)	0.001		0.147	0.000	0.000
	N	91	91	91	91	91
M3R	Pearson Correlation	0.562^**	0.153	1	0.298^**	0.571^**
	Sig. (2-tailed)	0.000	0.147		0.004	0.000
	N	91	91	91	91	91
α7nAChR	Pearson Correlation	0.236^*	0.561^**	0.298^**	1	0.679^**
	Sig. (2-tailed)	0.025	0.000	0.004		0.000
	N	91	91	91	91	91
ChAT	Pearson Correlation	0.324^**	0.370^**	0.571^**	0.679^**	1
	Sig. (2-tailed)	0.002	0.000	0.000	0.000
	N	91	91	91	91	91
* Correlation is significant at the 0.05 level (2-tailed).
** Correlation is significant at the 0.01 level (2-tailed).

Strong correlation, ± 0.50 and ± 1; Moderate correlation, ± 0.30 and ± 0.49; Weak correlation, ± 0.29

ISSN: 1471-2407