Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Cholinergic signaling influences the expression of immune checkpoint inhibitors, PD-L1 and PD-L2, and tumor hallmarks in human colorectal cancer tissues and cell lines

Fig. 1

Expression of immunosuppressive markers PD-L1 and PD-L2 in human tissues from colorectal cancer (CRC) patients diagnosed with early stages, I + II (A-A’’’) and advanced stages, III + IV (B-B’’’). Tissues were labeled with the nuclei marker DAPI (blue; A and B), PD-L1 (green; A’ and B’), PD-L2 (red; A’’ and B’’), and all markers merged (A’’’ and B’’’). The scale bar represents 50 μm. Bar graphs displaying the mean fluorescence of PD-L1 (C) and PD-L2 (D) in tissues from patients with early and advanced stages of CRC. Data presented as mean ± standard error of the mean (SEM), early stages I + II n = 49 and advanced stages III + IV n = 42. Student t-test, ****p < 0.0001

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us