Table 1 Significant MR analysis results

BCa

Actinobacteria (class)

2

166.914

IVW

1.546

1.018—2.349

0.041

Bifidobacteriaceae (family)

3

196.473

IVW

1.505

1.040—2.179

0.030

Weighted median

1.522

1.005—2.305

0.047

Ruminococcustorquesgroup

1

31.285

Wald ratio

3.656

1.248—10.706

0.018

Allisonella

1

32.374

Wald ratio

0.534

0.348—0.818

0.004

Bifidobacterium (genus)

3

200.670

IVW

1.496

1.039—2.154

0.030

Weighted median

1.512

1.011—2.260

0.044

Bifidobacteriales (order)

3

196.473

IVW

1.505

1.040—2.180

0.030

Weighted median

1.522

1.012—2.290

0.044

Actinobacteria (phylum)

2

112.438

IVW

1.765

1.034—3.013

0.037

PCa

Allisonella (genus)

1

32.374

Wald ratio

0.894

0.805—0.994

0.038

KCa

Ruminococcustorquesgroup (genus)

1

31.285

Wald ratio

3.798

1.154—12.504

0.028

Erysipelatoclostridium (genus)

1

34.619

Wald ratio

2.310

1.007—5.301

0.048