Fig. 2

Analysis of Young’s modulus of musculoskeletal cancer cell lines and heathy controls. (A) Box plots (medians, first and third quartiles, minimum, maximum) of the cellular stiffness (kPa) for each cell line is displayed. Outliers are depicted by circles. Healthy control cells were stiffer than their corresponding neoplastic cell line (p < 0.001), only exception being the chondrocytes that exhibited a lower stiffness than the chondrosarcoma cell line (p < 0.001). (B) Representative force-distance curves for various cell types. (C) Images showing histogram distribution of elastic modulus of all cell types.*** p < 0.001. Abbreviations: MSC- mesenchymal stem cells, SKMC - skeletal muscle cells