Table 1 List of the top BioPlanet significant pathways regulated by HeberFERON as the result of CPEA.

bioplanet_1345

FOXM1 transcription factor network

1.87E-05

AURKB, BIRC5, CCNA2, CENPF, FOXM1, CENPA, CCNB2, CCNB1, PLK1, NEK2

bioplanet_592

Aurora B signaling

1.03E-04

STMN1, AURKB, CDCA8, BIRC5, CENPA, NCAPG, INCENP, KIF23, KIF20A

bioplanet_1622

Phosphorylation of Emi1

3.82E-04

FBXO5, CDC20, CCNB1, PLK1

bioplanet_67

Stathmin and breast cancer resistance to antimicrotubule agents

1.40E-03

HIST1H4C, STMN1, CREB1, OAS1, USP18, HLA-B, STAT1, GBP1, CXCL10, PRKACB, IRF1, IFIT2, KAT2B, IFI6, TAP1, ISG15, EIF2AK2, RNF14, CCNB1, STAT2, PSMB9, IRF9

bioplanet_1327

Polo-like kinase 1 (PLK1) pathway

1.79E-03

FBXO5, CDC20, PRC1, INCENP, CCNB1, SPC24, PLK1, KIF20A

bioplanet_1757

Hypertrophy pathway

5.99E-03

IFRD1, ATF3, VEGFA, CYR61, IL1A

bioplanet_1391

APC/C activator regulation between G1/S and early anaphase

7.36E-03

FBXO5, CDC20, UBE2C, CCNB1, PLK1

bioplanet_1363

Delta Np63 pathway

1.09E-02

NRG1, FASN, RRAD, TOP2A, CCNB2, IL1A, RAB38

bioplanet_235

Cytokine-cytokine receptor interaction

1.31E-02

TNFSF13B, CSF3, IL11RA, INHBE, CXCL5, TNFSF10, CSF1R, CXCL10, CCL2, IL20RB, CCL20, CXCL2, LEP, VEGFA, IL1A, IL6, IL24, TNFRSF10D, CCL8

bioplanet_884

APC/C- and Cdc20-mediated degradation of Nek2A

1.47E-02

MAD2L1, CDC20, UBE2C, CCNB1, NEK2

bioplanet_1511

Cyclin A/B1-associated events during G2/M transition

1.49E-02

CCNA2, CCNB2, CCNB1, PLK1

bioplanet_195

p53 activity regulation

1.92E-02

GADD45A, KAT2B, SESN2, CCNA2, CCNE2, SHISA5, CCNB2, PMAIP1, GTSE1, CCNB1, CCND2

bioplanet_1575

Kinesins

1.95E-02

KIF22, KIFC1, KIF11, KIF23, KIF20A

bioplanet_1139

MicroRNA regulation of DNA damage response

2.19E-02

CREB1, MCM7, GADD45A, CCNE2, CCNB2, PMAIP1, CCNB1, CCND2

bioplanet_1409

Mitotic prometaphase

2.82E-02

ZWINT, CDC20, CENPF, CENPA, INCENP, PLK1