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Table 3 False positive report probability power and value

From: Association between IL-10 gene polymorphisms (− 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis

Genetic model

OR

(95%CI)

FPRP

P value

Statistical power

Prior probability

0.25

0.1

0.01

0.001

-1082 A/G

       

Dominant

       

Non-Asian

0.62 (0.45–0.86)

0.004

0.321

0.038

0.105

0.564

0.929

Heterozygous)

       

Overall

0.82 (0.67–0.99)

0.039

0.982

0.106

0.263

0.797

0.975

Non-Asian

0.60 (0.43–0.85)

0.004

0.267

0.043

0.12

0.6

0.938

Allelic

       

Non-Asian

0.80 (0.64–0.99)

0.04

0.953

0.112

0.275

0.806

0.977

-819 T/C

       

Dominant

       

Non-Asian

1.47 (1.02–2.13)

0.042

0.543

0.188

0.409

0.884

0.987

Recessive

       

Non-Asian

1.99 (1.03–3.86)

0.042

0.202

0.383

0.651

0.954

0.995

Homogenous

       

Non-Asian

2.18 (1.13–4.23)

0.021

0.134

0.321

0.587

0.940

0.994

  1. FPRP: False positive report probability. Statistical power is the power to detect an odds ratio of 1.5 with the genetic variant (or, 0.67 = 1/1.5 for protective effect). The results in bold implies noteworthiness of association at 0.2 level by FPRP. Not performed FPRP test for IL10 (-592 A/C) as there was no significant association with hepatocellular carcinoma risk (See Table 2)
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BMC Cancer

ISSN: 1471-2407

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