Table 2 Associations with the risk of hepatocellular carcinoma
SNP | Number of studies included | Total participants | Genetic Model | Effect estimates, OR (95%CI); p value | ||
|---|---|---|---|---|---|---|
-1082 A/G | 9 (5 Asian group, 4 non-Asian group) | 3089 | Overall | Asian group | Non-Asian group | |
Dominant | 0.85 (0.70–1.03) [p:0.09] | 1.01 (0.79–1.29) [p:0.95] | 0.62 (0.45–0.86) [p:0.004] | |||
Recessive | 1.10 (0.79–1.54) [p:0.56] | 1.30 (0.80–2.13) [p:0.29] | 0.97 (0.62–1.52) [p:0.88] | |||
Heterozygous) | 0.82 (0.67–0.99) [p:0.04] | 0.97 (0.75–1.25) [p:0.65] | 0.60 (0.43–0.85) [p:0.007] | |||
Homozygous | 0.91 (0.64–1.30) [p:0.61] | 1.20 (0.72–1.99) [p:0.65] | 0.71 (0.43–1.17) [p:0.51] | |||
Allelic ( | 0.92 (0.80–1.07) [p:0.28] | 1.05 (0.86–1.29) [p:0.63] | 0.80 (0.64–0.99) [p:0.04] | |||
-819 T/C | 8 (6 Asian group, 2 non-Asian group) | 3332 | Overall | Asian group | Non-Asian group | |
Dominant | 1.25 (1.05–1.48) [p:0.37] | 1.19 (0.98–1.45) [p:0.27] | 1.47 (1.02–2.13) [p:0.032] | |||
Recessive | 1.10 (0.81–1.50) [p:0.] | 0.96 (0.74–1.26) [p:0.] | 1.99 (1.03–3.86) [p:0.] | |||
Heterozygous | 1.20 (1.00-1.43) [p:0.73] | 1.19 (0.97–1.46) [p:0.49] | 1.23 (0.82–1.84) [p:0.93] | |||
Homozygous | 1.17 (0.80–1.72) [p:0.37] | 0.97 (0.65–1.44) [p:0.12] | 2.18 (1.13–4.23) [p:0.03] | |||
Allelic | 1.08 (0.89–1.32) [p:0.35] | 0.98 (0.81–1.19) [p:0.11] | 1.59 (0.96–2.63) [p:0.64] | |||
-592 A/C | 11 (10 Asian group, 1 non-Asian group) | 7516 | Overall | Asian group | Non-Asian group | |
Dominant | 0.90 (0.68–1.18) [p:0.44] | 0.86 (0.63–1.16) [p:0.32] | 1.29 (0.82–2.03) [p:0.27] | |||
Recessive TT vs. CT | 0.89 (0.72–1.11) [p:0.31] | 0.86 (0.69–1.08) [p:0.2] | 1.45 (0.75–2.78) [p:0.26] | |||
Heterozygous | 0.96 (0.75–1.22) [p:0.31] | 0.93 (0.71–1.21) [p:0.57] | 1.21 (0.75–1.96) [p:0.43] | |||
Homozygous | 0.93 (0.77–1.12) [p:0.43] | 0.91 (0.75–1.10) [p:0.33] | 1.32 (0.66–2.63) [p:0.44] | |||
Allelic | 0.90 (0.76–1.08) [p:0.25] | 0.87 (0.72–1.05) [p:0.15] | 1.26 (0.91–1.74) [p:0.17] | |||