Table 1 Characteristics of study
Author, yr [ref] | Yr of publication | Country | Setting | Ethnic group | Samples (case/ control) | Age in yr1 | Male%1 | Underlying cause | Polymorphism | Genotyping method | HWE |
|---|---|---|---|---|---|---|---|---|---|---|---|
Aroucha 2016 [34] | 2016 | Brazil | Hospital | Non-Asian | 108/280 | 62.7 ± 8.7 | 68.5 | HCV related HCC | -1082 A/G.-819 C/T, -592 A/C | TaqMan | Yes |
Bahgat 2015 [35] | 2015 | Egypt | Community clinic | Non-Asian | 50/50 | 52.30 ± 4.41 | 82 | HCV related HCC | -1082 A/G | RT-PCR | Yes |
Barooh 2020 [36] | 2020 | India | OPD | Asian | 60/306 | 54.8 ± 9.1 | 49 | HCV related HCC | -1082 A/G.-819 C/T, -592 A/C | PCR-RFLP | No |
Bei 2014 [37] | 2014 | China | Hospital | Asian | 720/784 | 48.65 ± 11.03 | 86 | Newly diagnosed HCC | -592 A/C | TaqMan | Yes |
Bouzgarrou 2009 [38] | 2009 | Tunisia | Hospital | Non-Asian | 58/145 | 61.6 ± 9.8 | 34.5 | HCV related HCC | -1082 A/G | AS- PCR- | Yes |
El-Baky 2020 [39] | 2020 | Egypt | Hospital | Non-Asian | 54/92 | 64.16 ± 12.1 | 90.7 | HCV complicated with HCC | -1082 A/G | TaqMan | No |
Heneghan 2003 [40] | 2003 | China | Hospital | Asian | 98/175 | 55 year (range: 14–77 year) | 92.9 | HBV related HCC | -1082 A/G.-819 C/T, -592 A/C | PCR-SSCP | Yes |
Migita 2003 [41] | 2003 | Japan | OPD | Asian | 48/188 | 62.5 ± 8.9 | 81.25 | HBV related HCC | -1082 A/G.-819 C/T, -592 A/C | PCR-SSP | No |
Peng 2016 [42] | 2016 | China | Hospital | Asian | 173/182 | 56.32 ± 7.55 | 36.42 | HBV related HCC | -1082 A/G.-819 C/T, -592 A/C | PCR-RFLP | Yes |
Saleh 2020 [43] | 2020 | Egypt | HCC clinic | Non-Asian | 73/85 | 56.21 ± 4.62 | 58.9 | HCV related HCC | -819 C/T | RT-PCR | No |
Saxena 2014 [44] | 2014 | India | OPD | Asian | 59/331 | 55.31 ± 12.67 | 18.66 | HBV related HCC | -819 C/T, -592 A/C | AS-PCR | No |
Shin 2003 [45] | 2003 | Korea | Hospital | Asian | 230/792 | Only cutoff age | HBV related HCC | -1082 A/G, -592 A/C | MAPA | No | |
Tseng 2006 [46] | 2006 | Taiwan | Hospital | Asian | 208/528 | 55 (23–85) | HBV related HCC | -592 A/C | PCR/RFLP | Yes | |
Wang 2019 [47] | 2019 | China | Hospital | Asian | 554/612 (277/306) | ≤ 35- >50 | 84.8 | HBV-related HCC2 | -819 C/T, -592 A/C | PCR-based | No |
Zhou 2017 [48] | 2017 | China | Hospital | Asian | 430/709 | < 55-≥55 | 88.1 | HBV-related HCC | -592 A/C | MassARRAY | Yes |