Fig. 3
From: BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness
The marked downregulation of antigen presentation genes found via a RNA-seq analysis of BCL7B-deficient cells is reported as the FPKM. a The expression levels of the CASP1 gene, an initiator of inflammation and the immune response cascade, in terms of FPKM. b The expression levels of the NLRC5 (CITA) gene, a key cotransactivator of the MHC class I pathway. c-f The expression levels of representative NLRC5-downstream genes: (c) TAP1, (d) PSMB9 (LMP2), (e) HLA-B, and (f) HLA-E. g The expression levels of the IRF1 gene, a transcription factor of CIITA, which has also been implicated in regulating class I MHC expression. h The expression levels of the CIITA gene, a key transactivator of the MHC class II pathway. c, i-l The expression levels of representative CIITA-downstream genes: (c) TAP1, (i) HLA-DQA1, (j) HLA-DQA2, (k) HLA-DOA, and (l) HLA-DQB2. m Simplified diagram showing the relationships of antigen presentation molecules