Fig. 8

WT1 mediates the tumour suppressing effects of miR-498-5p in NSCLC. (A) Western blot of WT1, MYC, MMP2 after WT1 was restored in miR-498-5p-overexpressing A549 and H1299 cells. (B) Growth curves of the indicated cells assessed by CCK-8 assays. (C) Colony formation results. Representative images (left) and quantification graph (right) were provided. (D) Transwell invasion results. Representative images (left) and quantification graph (right) were provided. (E)In vivo xenograft tumour growth results of the indicated cells. Representative images (left), tumour volume (middle) and tumour weight (right) were provided. **P < 0.01, ***P < 0.001 (vs. miR-NC), ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 (miR-498-5p + WT1 vs. miR-498-5p). Scale bar, 200 μm