Fig. 6
Gemcitabine chemosensitivity in ATM-knockdown PC cell lines. Cytotoxicity was assessed using the MTT assay in MIA-PaCa2 and SUIT-2 cells. Differences in IC50 between ATM si-RNA (1&2) and ATM si-RNA con were compared; effects of ATM expression levels on gemcitabine sensitivity were calculated. MIA-PaCa2, IC50: con vs. si-1, p < 0.001; con vs. si-2, p < 0.001. SUIT-2, IC50: con vs. si-1, p < 0.001; con vs. si-2, p < 0.001. PC, pancreatic cancer; ATM, ataxia telangiectasia mutated; si-con/si-ATM1/si-ATM2, si-ATM RNA negative control/1/2