Fig. 3

RNA sequencing in ATM-knockdown PC cell lines. RNA sequencing was performed after transfection of PC cell lines with si-ATM and si-ATM-negative controls. (A) Common DEGs within a unique cluster of the four groups from the two cell lines were listed. DEGs were defined as genes with fold change > 2, p-value < 0.05, and FDR < 0.001. (B) Heatmap analysis of seven DEGs in two cell lines. PC, pancreatic cancer; ATM, ataxia telangiectasia mutated; DEGs, differentially expressed genes