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Table 4 Pseudoprogression and radionecrosis related to radiotherapy

From: Propensity score-matched analysis comparing hippocampus-avoidance whole-brain radiotherapy plus simultaneous integrated boost with hippocampus‑avoidance whole-brain radiotherapy alone for multiple brain metastases-a retrospective study in multiple institutions

Project

Pseudoprogression

Radionecrosis

occurrence time

3 months after radiotherapy

More than 6 months after radiotherapy

MRI enhancement

irregular enhancement within the lesion,significant occupancy effect

significant delayed phase enhancement

incidence rate

20-30%, further observation gradually decreases or even disappears

2-18%, progressive and irreversible

18FDG PET-CT

Hypermetabolism

Hypometabolism

  1. Abbreviations: MRI Magnetic resonance imaging, 18FDG PET-CT 18F fluorodeoxygluecose position emission tomography imaging