Table 1 Baseline characteristics of patients
Patient Characteristic | HA-WBRT+SIB (n=56) | HA-WBRT (n=56) | P value |
|---|---|---|---|
Age(years), n (%) | 0.295 | ||
30~60 | 23(41) | 22(39) | |
60~80 | 33(59) | 34(61) | |
Gender, n(%) | 0.848 | ||
Male | 33(59) | 32(57) | |
Female | 23(41) | 24(43) | |
KPS scores, n(%) | 0.894 | ||
90 | 13(23) | 11(20) | |
80 | 34(61) | 36(64) | |
70 | 9(16) | 9(16) | |
Primary focus, n(%) | 0.194 | ||
NSCLC | 39(69) | 41(73) | |
Breast cancer | 6(10.5) | 3(5) | |
Esophageal cancer | 6(10.5) | 2(4) | |
Other cancer | 5(9) | 10(18) | |
No. of BMs, mean(range), n | 7.89 (4-15) | 7.69 (4-15) | 0.733 |
Sum of maximum diameter of BMs mean (range), cm | 8.74 (3.5-19.1) | 7.79 (3.4-19.7) | 0.220 |
Volume PGTV, median (rang,cm3) | 11.47 (5.35-29.21) | 10.24 (5.2-30.13) | 0.211 |
maximum dose of the hippocampus median (rang, Gy) | 13.42(10.63-14.72) | 12.85(11.2-14.12) | 0.287 |
mean dose of the hippocampus, mean (rang, Gy) | 7.84(5.56-9.35) | 7.33(5.61-9.01) | 0.071 |
extracerebral metastases, n(%) | 0.552 | ||
Yes | 18(32) | 21(37) | |
No | 38(68) | 35(63) | |
Complications of BMs,n(%) | 0.237 | ||
Yes | 33(59) | 39(70) | |
No | 23(41) | 17(30) | |
Systemic therapy,n(%) | 0.696 | ||
Yes | 36(64) | 34(61) | |
No | 20(36) | 22(39) | |
Neurologic function status,n(%) | 0.897 | ||
NO neurologic symptoms:fully active at home/work without assistance | 29(51.8) | 26(46.4) | |
Minor neurologic symptoms:fully active at home/work without assistance | 19(33.9) | 21(37.5) | |
Moderate neurologic symptoms:fully active at home/work but requires assistance | 7(12.5) | 7(12.5) | |
Moderate neurologic symptoms:less than fully active at home/work and requires assistance | 1(1.8) | 2(3.6) | |
Education(>high school v.≤ high school),n(%) | 0.980 | ||
No formal education | 3(5.3) | 5(8.9) | |
Primary school | 26(46.43) | 24(42.9) | |
Secondary school | 14(25) | 16(28.5) | |
High school | 7(12.5) | 6(10.7) | |
College or associate’s degree | 2(3.6) | 2(3.6) | |
Bachelor’s degree | 2(3.6) | 2(3.6) | |
Master’s degree | 2(3.6) | 1(1.8) | |
Doctoral or professional degree | 0 | 0 | |