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Fig. 8 | BMC Cancer

Fig. 8

From: Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion

Fig. 8

Reduced expression of SK1, SK2 and DESG1 genes after treatment under hypoxic conditions. NCH82 cells treated with the vehicle control (DMSO), 48 µM TMZ, 2.66 µM SKI-II and the combination (TMZ + SKI-II) for 24 h under normoxia (21% O2) and hypoxia (3% O2) were analyzed for the expression of SK1 (sphingosine kinase 1); SK2 (sphingosine kinase 2); and DESG1 (dihydroceramide desaturase 1) by RT-qPCR. Data represent mean (± SD) of n = 3. Two-way ANOVA followed by Tukey’s multiple comparisons test was performed for statistical analysis

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BMC Cancer

ISSN: 1471-2407

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