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Fig. 5 | BMC Cancer

Fig. 5

From: Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion

Fig. 5

SKI-II alone and in combination with temozolomide (TMZ) induces dilation and fragmentation of the ER. NCH82 cells were treated at 3% O2 with (A) the vehicle control (DMSO), (B) 48 µM TMZ, (C) 2.66 µM SKI-II, and (D) the combination (TMZ + SKI-II) for 48 h and further analyzed via transmission electron microscopy. Dotted squares are regions of interest. N – nucleus; M – mitochondria; ER – endoplasmic reticulum. Black arrows show ribosomes

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BMC Cancer

ISSN: 1471-2407

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