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Fig. 10 | BMC Cancer

Fig. 10

From: Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion

Fig. 10

The combination exerts a very weak cytotoxic effect on GSC cells. The 1080-DMSO and 1080-TMZ cells were analyzed by flow cytometry after treatment with vehicle control (DMSO), 48 µM TMZ, 2.66 µM SKI-II, and the combination (TMZ + SKI-II) for 5 days under normoxia (21% O2) and hypoxia (3% O2). Quantification of PI- and AV-FITC-labeled GSC cells was performed using the software FlowJo. Data are presented as percent of total cells; n = 3

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BMC Cancer

ISSN: 1471-2407

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