TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk

Craig, Daniel J.; Crawford, Erin L.; Chen, Heidi; Grogan, Eric L.; Deppen, Steven A.; Morrison, Thomas; Antic, Sanja L.; Massion, Pierre P.; Willey, James C.

doi:10.1186/s12885-023-11266-7

BMC Cancer

Table 1 Patient Demographics

From: TP53 mutation prevalence in normal airway epithelium as a biomarker for lung cancer risk

Sample #	Patient ID	Cancer Status	PY^c	Sex	Age^d	Smoking Status	Histology	Brock Risk Score	TP53 Mutation Prevalence^g	Protocol ID^h
Sample #	Patient ID	Cancer Status	PY^c	Sex	Age^d	Smoking Status	Histology	Risk Score (× 100)	TP53 Mutation Prevalence^g	Protocol ID^h
1	7047	NC^a	25	M	57	Former	NC	0.86	0.000	0398
2	7768	NC	20	F	52	Current	NC	1.07	0.005	0398
3	8115	NC	36	M	56	Former	NC	0.66	0.000	1078
4	9277	NC	20	F	60	Former	NC	0.94	0.000	1078
5	9680	NC	31	F	63	Former	NC	0.97	0.010	1078
6	12,028	NC	14.5	F	50	Current	NC	0.4	0.015	0398
7	12,318	NC	6	M	71	Former	NC	0.68	0.005	0398
8	7871	NC	45	M	69	Former	NC	9.31	0.020	0398
9	8027	NC	78	F	55	Current	NC	5.88	0.026	1078
10	8182	NC	110	M	61	Former	NC	11.07	0.005	1078
11	8202	NC	78	M	66	Current	NC	7.05	0.010	1078
12	8356	NC	42	F	72	Former	NC	6.15	0.005	1078
13	9299	NC	75	M	64	Current	NC	5.26	0.000	1078
14	11,858	NC	20	M	74	Former	NC	6.59	0.000	0398
15	7878	NC	30	F	58	Current	NC	2.15	0.005	1078
16	7319	NC	0	M	28	Never	NC	0.04	0.005	0398
17	7282	NC	0	F	33	Never	NC	0.08	0.000	0398
18	7291	NC	0	M	38	Never	NC	0.1	0.010	0398
19	10,660	NC	0	F	41	Never	NC	0.14	0.000	0398
20	9425	NC	66	F	70	Current	NC	7.16	0.015	1078
21	9022	NC	51	M	60	Former	NC	4.16	0.020	1078
22	8978	NC	51	M	65	Current	NC	8.48	0.000	1078
23	12,444	NC	60	F	68	Current	NC	11.28	Not measured	1078
38	11,583	NC	39	M	63	Former	NC	1.38	0.005	0398
39	9420	NC	62.5	F	59	Former	NC	2.1	0.000	1078
40	7769	NC	0	M	70	Never	NC	1.65	0.000	0398
41	11,202	NC	0	F	52	Never	NC	0.55	0.000	0398
42	11,917	NC	0	F	81	Never	NC	6.93	0.000	0398
43	15,667	NC	0	M	57	Never	NC	1.18	0.005	0398
44	7979	NC	62	F	61	Former	NC	1.73	0.000	1078
24	6359	CA^b	44	M	68	Former	SQ^e	8.55	0.041	0398
25	11,143	CA	47	M	65	Current	AD^f	16.79	0.005	0398
26	11,761	CA	78	M	49	Current	AD	5.25	0.026	0398
27	11,841	CA	72	M	51	Current	AD	2.19	0.026	0398
28	11,704	CA	72	F	61	Current	SQ	14.6	0.031	0398
29	7481	CA	150	M	78	Former	SQ	14.95	0.005	0398
30	8841	CA	185.5	M	76	Former	SQ	22.88	0.041	0398
31	7725	CA	60	M	79	Current	SQ	25.61	0.041	0398
32	8358	CA	50	M	60	Current	SQ	9.42	0.056	0398
33	8439	CA	92	M	62	Former	SQ	5.3	0.051	0398
34	7801	CA	25	F	65	Current	SQ	2.65	0.036	0398
35	7509	CA	100	M	68	Current	SQ	13.74	0.026	0398
36	7492	CA	40	M	63	Current	SQ	4.29	0.020	0398
37	8340	CA	108	M	64	Former	SQ	9.93	0.031	0398
45	12,847	CA	15	F	59	Former	AD	2.28	0.000	0398
46	3857	CA	47	F	67	Former	AD	7.17	0.010	0398
47	3955	CA	88	F	58	Current	AD	14	0.031	0398
48	6077	CA	88	F	58	Current	AD	14.37	0.010	0398
49	7757	CA	45	M	74	Former	AD	11.15	0.097	0398
50	7781	CA	99.9	F	60	Former	AD	4.95	0.031	0398
51	7789	CA	30	F	77	Former	AD	12.04	0.005	0398
52	7862	CA	74	M	68	Former	AD	4.42	0.010	0398
53	9517	CA	40	F	61	Former	AD	3.09	0.000	0398
54	9641	CA	50	F	64	Current	AD	7.31	0.031	0398
55	9707	CA	60	F	77	Former	AD	11.22	0.005	0398
56	9798	CA	47	F	69	Former	AD	8.52	0.056	0398
57	11,246	CA	96	F	65	Current	AD	7.35	0.010	0398
58	12,911	CA	15	M	72	Former	AD	5.3	0.046	0398
59	14,611	CA	60	F	69	Current	AD	10.43	0.005	0398
60	14,813	CA	61.5	M	59	Former	AD	6.24	0.031	0398

^a Noncancer
^b Lung cancer
^c Pack-years
^dAge at Collection
^e Squamous cell carcinoma
^f Adenocarcinoma
^g TP53 mutations/193 bp targeted/subject
^h See Methods Sect. 0398—Molecular Predictors of Lung Cancer Behavior, 1078—Nashville Lung Screening Trial

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ISSN: 1471-2407

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