Table 2 Pathogenic variants detected in breast cancer subgroups
Any variant class 4/5a, n (%) | P Value | |
|---|---|---|
Breast cancer, NHG grade (n = 2984) | P = 2.00 × 10–14 | |
NHG grade 1 (n = 401) | 31 (7.7) | |
NHG grade 2 (n = 1234) | 154 (12.5) | |
NHG grade 3 (n = 1349) | 291 (21.6) | |
Breast cancer, morphological subtype (n = 3376) | P = 1.20 × 10–9 | |
Ductal (n = 2735) | 475 (17.4) | |
Lobular (n = 301) | 21 (7.0) | |
Medullary (n = 61) | 24 (39.3) | |
Other invasive (n = 279) | 42 (15.1) | |
Breast cancer, estrogen receptor status (n = 3291) | P = 2.38 × 10–9 | |
ER positive (n = 2411) | 345 (14.3) | |
ER negative (n = 880) | 203 (23.1) | |
Breast cancer, molecular subtype (n = 2830) | P = 6.54 × 10–21 | |
ER + , HER2-, NHG 1 (Luminal A-like, n = 334) | 25 (7.5) | |
ER + , HER2-, NHG 2 (Luminal not classified, n = 859) | 102 (11.9) | |
ER + , HER2-, NHG 3 (Luminal B-like, n = 404) | 97 (24.0) | |
ER + , HER2 + (HER2-positive/Luminal, n = 430) | 57 (13.3) | |
ER-, HER2 + (HER2-positive/non-Luminal, n = 194) | 24 (12.4) | |
ER-, PR-, HER2- (Triple-negative, n = 609) | 165 (27.1) | |