Skip to main content

Table 2 Comparison of mobilization efficacy in the PEG group and the rhG-CSF group

From: A novel PEGylated form of granulocyte colony-stimulating factor, mecapegfilgrastim, for peripheral blood stem cell mobilization in patients with hematologic malignancies

Characteristic

PEG group

N = 36 cases

rhG-CSF group

N = 31 cases

Statistical value

P value

Premobilization WBC (×10^9/L)

4.67(1.19–9.89)

4.67(1.68–10.93)

0.692

0.489

Premobilization lymphocyte/monocyte count ratio

1.91(0.84–5.29)

2.25(0.15–6.19)

0.953

0.341

Premobilization HGB (g/L)

122(59–159)

122(61–139)

0.704

0.481

Premobilization PLT (×10^9/L)

176(74–306)

169(7-498)

0.535

0.593

Precollection WBC (×10^9/L)

52.31 ± 18.26

40.70 ± 15.30

2.794

0.007

Precollection lymphocyte/monocyte count ratio

0.55(0.28–8.14)

0.59(0.19–4.22)

0.747

0.455

Precollection HGB (g/L)

114 ± 19

112 ± 20

0.397

0.693

Precollection PLT (×10^9/L)

129(49–260)

126(68–459)

0.157

0.875

Collection of MNC counts (10^8/kg)

16.83(6.88–47.60)

16.00(3.48–36.61)

0.666

0.505

Collection of CD34 + cell counts (10^6/kg)

3.62(0.32–13.26)

2.92(0.05–9.85)

1.346

0.178

Mobilization efficacy

  

1.451

0.484

 Failure

19.4% (7/36)

32.3% (10/31)

  

 Standard

52.8% (19/36)

45.2% (14/31)

  

 Optimal

27.8% (10/36)

22.6% (7/31)

  

Collection of CD34 + cell counts with plerixafor (10^6/kg)

3.64(0.32–13.26)

3.92(0.40–9.17)

0.313

0.754

Time of neutrophil implantation (days)

9.96 ± 0.87

9.64 ± 1.22

0.959

0.344

Time of platelet implantation (days)

11.88 ± 2.41

11.79 ± 1.76

0.135

0.893

Occurrence of infection

  

0.000

1.000

 Yes

77.8% (21/27)

78.6% (11/14)

  

 No

22.2% (6/27)

21.4% (3/14)

  

Transfusion of red blood cell (U)

0(0–6)

0(0–3)

0.159

0.873

Transfusion of PLT (therapeutic volumes)

2(0–5)

1.5(1–4)

0.044

0.965

Hospitalization duration (days)

23(19–30)

24(19–39)

1.112

0.266

  1. rhG-CSF, recombinant human granulocyte colony stimulating factor; PEG group, Mobilization of hematopoietic stem cells with mecapegfilgrastim; WBC, white blood cell; HGB, hemoglobin; PLT, platelet