Fig. 1

Schematic presentation of study design and AAT therapy effects on mice colon length and body weight. A. Mice were injected with AOM (day 0) followed by three cycles of 2.5% DSS in drinking water. AOM/DSS-AAT group received i.p. AAT on weeks 15, 16 and 17. At week 18, all mice were sacrificed for further analysis. B. Representative gross macroscopic image of the colon of AOM/DSS and AOM/DSS + AAT. C. Box plots show body weight differences between experimental groups of mice. D. Colon length, box plots show colon length in different experimental groups. E. Disease Activity Index (DAI) score.a composite measure of weight loss, stool consistency and blood in stool. A student’s t-test was used to compare between each two groups. A value of p < 0.05 was considered a significant