Fig. 6
Expression of CD44, KRAS, and VEGFA in GA patient tumors. A Gene expression of CD44, KRAS, and VEGF-A in gastric tumors compared to adjacent normal tissues. B Hierarchical clustering of gene expression in 83 patient tumors based on the log2 fold-change in gene expression in tumor compared to adjacent normal tissue. Clinical information, including tumor location, Lauren classification, TNM stage, and the molecular classifications by Splicing, ACRG, and TCGA methods are indicated for the three clusters defined by CD44 expression (low, intermediate, and high). C Box plots of KRAS and VEGFA expression in each CD44 patient cluster. D Kaplan–Meier overall survival curves stratified by expression of VEGF-A in the FMUUH cohort