Fig. 2
From: A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation
Top 10% of the differentially methylated CpGs in several cancers such as (A) thyroid cancer and (B) sarcoma when comparing tumour samples with the highest and lowest quartile of SETD2 expression, clustered using the McQuitty clustering method and distance measure given by the Euclidean distance. The genomic distribution of hypomethylated CpGs in gene bodies in (C) thyroid cancer is significantly lower than expected whereas (D) in sarcoma, hypomethylated CpGs show a strong gene body enrichment; Illumina array shows the distribution of CpGs in the entire 450k methylation array; β-value represents level of methylation; 3’UTR: 3’ untranslated region, 5’UTR: 5’ untranslated region; TSS1500: 1500 bp upstream of transcription start site, TSS200: 200 bp upstream of transcription start site.