The role of heavy metals in the development of colorectal cancer

BMC Cancer

Table 4 Clinical characteristics of 101 CRC patients in this study

Variables	MSI	MSS	p value
Age (years)	61.07 ± 9.97	60.65 ± 10.48	0.853
Sex
Male	13	37	0.420
Female	17	34
BMI (kg/m²)	23.50 ± 3.04	24.03 ± 3.74	0.500
Smoking			0.648
Yes	12	25
No	18	46
Drinking			0.334
Yes	5	7
No	25	64
Diabetes			0.471
Yes	1	5
No	29	66
Hypertension			0.243
Yes	12	20
No	18	51
CAD			0.946
Yes	2	5
No	28	66
Tumor stage			0.016
I-II	21	31
III-IV	9	40
Degree of tumor differentiation			0.817
Low, middle-low	8	19
Middle, high	21	51
NA	1	1
Family history of tumor			0.260
Yes	2	3
No	27	68
NA	1	0
Tumor size (cm)			0.028
≤ 3	2	0
>3	28	71
Nerve invasion			0.076
Yes	2	15
No	28	56
Vascular invasion			0.035
Yes	2	18
No	27	53
NA	1	0
Lymph node metastasis			0.016
Yes	9	40
No	21	31
Distant metastasis			0.292
Yes	2	10
No	28	61
BRAF V600E			0.035
Mutation	4	1
Wild	26	69
NA	0	1
NRAS Codon 12/13			0.021
Mutation	3	0
Wild	27	70
NA	0	1
mRNA expression level of ERCC1	1.71 ± 2.30	2.75 ± 2.20	0.035

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