Immune cells | Immune checkpoint | Purity | CBX1 | CBX2 | CBX3 | CBX5 | CBX6 | CBX8 | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cor | p | cor | p | cor | P | Cor | P | Cor | P | Cor | P | Cor | P | ||
CD8 + T cell | CD8A | 0.544 | *** | 0.332 | * | 0.291 | 0.065 | 0.399 | ** | 0.427 | ** | 0.580 | *** | 0.087 | 0.589 |
CD8B | 0.411 | ** | 0.055 | 0.733 | 0.045 | 0.779 | 0.147 | 0.359 | 0.239 | 0.132 | 0.229 | 0.151 | 0.094 | 0.561 | |
T cell (general) | CD3D | -.709 | *** | 0.116 | 0.472 | 0.174 | 0.276 | 0.100 | 0.533 | 0.095 | 0.555 | 0.034 | 0.832 | 0.102 | 0.524 |
CD3E | 0.750 | *** | 0.472 | 0.664 | 0.276 | 0.483 | 0.533 | 0.699 | 0.555 | 0.704 | 0.832 | 0.874 | 0.524 | 0.695 | |
CD2 | 0.737 | *** | 0.121 | 0.452 | 0.011 | 0.946 | 0.114 | 0.480 | 0.172 | 0.281 | 0.384 | 0.013 | 0.045 | 0.779 | |
B cell | CD19 | 0.145 | 0.361 | 0.036 | 0.823 | 0.019 | 0.908 | 0.069 | 0.667 | 0.069 | 0.669 | 0.305 | 0.053 | 0.087 | 0.589 |
CD79A | 0.032 | 0.841 | 0.189 | 0.236 | 0.283 | 0.073 | 0.346 | * | 0.246 | 0.121 | 0.017 | 0.916 | 0.529 | *** | |
Monocyte | CD86 | 0.385 | * | 0.465 | ** | 0.067 | 0.678 | 0.141 | 0.379 | 0.424 | ** | 0.491 | ** | 0.162 | 0.312 |
CD115 (CSF1R) | 0.514 | *** | 0.483 | ** | 0.147 | 0.360 | 0.202 | 0.205 | 0.449 | ** | 0.590 | *** | 0.070 | 0.664 | |
TAM | CCL2 | 0.252 | 0.107 | 0.383 | * | 0.001 | 0.996 | 0.015 | 0.927 | 0.221 | 0.164 | 0.303 | 0.054 | 0.121 | 0.451 |
CD68 | 0.410 | ** | 0.196 | 0.219 | 0.036 | 0.823 | 0.020 | 0.901 | 0.171 | 0.286 | 0.490 | 0.001 | 0.076 | 0.635 | |
IL10 | 0.211 | 0.180 | 0.466 | ** | 0.239 | 0.133 | 0.345 | * | 0.403 | ** | 0.563 | *** | 0.050 | 0.758 | |
M1 Macrophage | INOS (NOS2) | 0.195 | 0.216 | 0.252 | 0.112 | 0.084 | 0.602 | 0.073 | 0.651 | 0.171 | 0.286 | 0.286 | 0.070 | 0.137 | 0.392 |
IRF5 | 0.257 | 0.100 | 0.442 | ** | 0.108 | 0.503 | 0.084 | 0.601 | 0.375 | * | 0.425 | ** | 0.196 | 0.218 | |
COX2 (PTGS2) | 0.324 | * | 0.434 | ** | 0.159 | 0.319 | 0.223 | 0.161 | 0.438 | ** | 0.432 | ** | 0.027 | 0.868 | |
M2 Macrophage | CD163 | 0.084 | 0.597 | 0.254 | 0.109 | 0.054 | 0.737 | 0.098 | 0.541 | 0.156 | 0.330 | 0.489 | ** | 0.191 | 0.231 |
VSIG4 | 0.157 | 0.319 | 0.121 | 0.452 | 0.063 | 0.696 | 0.018 | 0.910 | 0.049 | 0.760 | 0.415 | ** | 0.237 | 0.135 | |
MS4A4A | 2.202 | 0.200 | 0.290 | 0.066 | 0.049 | 0.762 | 0.050 | 0.755 | 0.115 | 0.476 | 0.291 | 0.065 | 0.229 | 0.150 | |
Neutrophils | CD66b(CEACAM8) | 0.273 | 0.080 | 0.086 | 0.592 | 0.214 | 0.179 | 0.227 | 0.153 | 0.101 | 0.529 | 0.001 | 0.996 | 0.197 | 0.216 |
CD11b (ITGAM) | 0.309 | * | 0.260 | 0.101 | 0.082 | 0.610 | 0.100 | 0.535 | 0.257 | 0.104 | 0.337 | * | 0.234 | 0.140 | |
CCR7 | 0.498 | *** | 0.268 | 0.090 | 0.047 | 0.769 | 0.157 | 0.327 | 0.222 | 0.163 | 0.288 | 0.068 | 0.049 | 0.759 | |
NK cell | KIR2DL1 | 0.352 | * | 0.107 | 0.506 | 0.022 | 0.891 | 0.010 | 0.951 | 0.082 | 0.610 | 0.114 | 0.476 | 0.040 | 0.805 |
KIR2DL3 | 0.424 | ** | 0.158 | 0.324 | 0.074 | 0.647 | 0.023 | 0.885 | 0.226 | 0.156 | 0.092 | 0.569 | 0.070 | 0.663 | |
KIR2DL4 | 0.206 | 0.191 | 0.237 | 0.135 | 0.034 | 0.834 | 0.052 | 0.747 | 0.135 | 0.400 | 0.222 | 0.162 | 0.209 | 0.190 | |
KIR3DL1 | 0.285 | 0.067 | 0.133 | 0.406 | 0.131 | 0.416 | 0.019 | 0.908 | 0.159 | 0.322 | 0.199 | 0.212 | 0.010 | 0.951 | |
KIR3DL2 | 0.612 | *** | 0.281 | 0.075 | 0.307 | 0.051 | 0.163 | 0.307 | 0.301 | 0.056 | 0.268 | 0.090 | 0.017 | 0.916 | |
KIR3DL3 | 0.117 | 0.461 | 0.091 | 0.572 | 0.111 | 0.490 | 0.004 | 0.979 | 0.053 | 0.743 | 0.072 | 0.656 | 0.149 | 0.354 | |
KIR2DS4 | 0.239 | 0.127 | 0.163 | 0.309 | 0.305 | 0.052 | 0.252 | 0.112 | 0.175 | 0.274 | 0.227 | 0.154 | 0.152 | 0.343 | |
Dendritic cell | HLA-DPB1 | 0.207 | 0.188 | 0.335 | * | 0.186 | 0.245 | 0.157 | 0.327 | 0.223 | 0.162 | 0.170 | 0.288 | 0.072 | 0.656 |
HLA-DQB1 | 0.160 | 0.311 | 0.070 | 0.664 | 0.002 | 0.989 | 0.091 | 0.570 | 0.076 | 0.639 | 0.031 | 0.850 | 0.094 | 0.559 | |
HLA-DRA | 0.195 | 0.215 | 0.119 | 0.458 | 0.131 | 0.416 | 0.142 | 0.377 | 0.126 | 0.432 | 0.151 | 0.345 | 0.299 | 0.058 | |
HLA-DPA1 | 0.304 | * | 0.134 | 0.404 | 0.070 | 0.664 | 0.138 | 0.388 | 0.181 | 0.258 | 0.232 | 0.144 | 0.170 | 0.288 | |
BCDA-1 (CD1C) | 0.026 | 0.872 | 0.151 | 0.348 | 0.365 | * | 0.457 | ** | 0.268 | 0.090 | 0.113 | 0.480 | 0.499 | *** | |
BDCA-4 (NRP1) | -.263 | 0.092 | 0.591 | 0.000 | 0.352 | * | 0.276 | 0.080 | 0.518 | *** | 0.637 | *** | 0.054 | 0.737 | |
CD11c (ITGAX) | 0.533 | *** | 0.311 | * | 0.083 | 0.605 | 0.049 | 0.763 | 0.275 | 0.082 | 0.242 | 0.127 | 0.400 | ** | |
Th1 | TBX21 | 0.706 | *** | 0.178 | 0.265 | 0.055 | 0.732 | 0.017 | 0.918 | 0.135 | 0.401 | 0.353 | * | 0.242 | 0.128 |
STAT4 | 0.732 | *** | 0.315 | * | 0.005 | 0.977 | 0.091 | 0.572 | 0.242 | 0.128 | 0.310 | * | 0.099 | 0.538 | |
STAT1 | 0.451 | ** | 0.493 | ** | 0.214 | 0.180 | 0.242 | 0.128 | 0.444 | ** | 0.755 | *** | 0.117 | 0.467 | |
IFN-g (IFNG) | 0.537 | *** | 0.401 | ** | 0.231 | 0.146 | 0.301 | 0.056 | 0.347 | * | 0.665 | *** | 0.009 | 0.957 | |
TNF-a (TNF) | 0.236 | * | 0.242 | 0.128 | 0.223 | 0.160 | 0.122 | 0.446 | 0.386 | * | 0.383 | * | 0.060 | 0.711 | |
Th2 | GATA3 | 0.688 | *** | 0.273 | 0.084 | 0.110 | 0.493 | 0.118 | 0.462 | 0.314 | * | 0.417 | ** | 0.102 | 0.526 |
STAT6 | 0.065 | 0.684 | 0.859 | *** | 0.500 | *** | 0.567 | *** | 0.847 | *** | 0.693 | *** | 0.327 | * | |
STAT5A | 0.418 | *** | 0.101 | 0.531 | 0.116 | 0.469 | 0.214 | 0.179 | 0.046 | 0.775 | 0.069 | 0.666 | 0.144 | 0.370 | |
IL13 | 0.298 | 0.055 | 0.108 | 0.501 | 0.189 | 0.237 | 0.211 | 0.186 | 0.047 | 0.772 | 0.063 | 0.693 | 0.020 | 0.899 | |
Tfh | BCL6 | 0.181 | 0.251 | 0.429 | 0.005 | 0.294 | 0.062 | 0.412 | 0.007 | 0.328 | 0.037 | 0.177 | 0.269 | 0.303 | 0.054 |
IL21 | 0.411 | ** | 0.356 | * | 0.021 | 0.897 | 0.022 | 0.893 | 0.313 | * | 0.435 | ** | 0.160 | 0.317 | |
Th17 | STAT3 | 0.277 | 0.076 | 0.706 | *** | 0.411 | ** | 0.479 | ** | 0.693 | *** | 0.721 | *** | 0.144 | 0.368 |
IL17A | 0.508 | *** | 0.110 | 0.494 | 0.139 | 0.386 | 0.027 | 0.869 | 0.063 | 0.695 | 0.141 | 0.378 | 0.054 | 0.735 | |
Treg | FOXP3 | 0.633 | *** | 0.313 | * | 0.037 | 0.819 | 0.033 | 0.836 | 0.303 | 0.054 | 0.307 | 0.051 | 0.355 | * |
CCR8 | 0.477 | ** | 0.469 | ** | 0.222 | 0.164 | 0.228 | 0.152 | 0.468 | ** | 0.521 | *** | 0.428 | ** | |
STAT5B | 0.323 | 0.037 | 0.639 | *** | 0.408 | ** | 0.435 | ** | 0.648 | *** | 0.722 | *** | 0.360 | * | |
TGFb (TGFB1) | 0.517 | *** | 0.628 | *** | 0.468 | ** | 0.328 | * | 0.527 | *** | 0.723 | *** | 0.417 | ** | |
Tex | PD-1 (PDCD1) | 0.533 | *** | 0.115 | 0.473 | 0.256 | 0.107 | 0.397 | * | 0.226 | 0.155 | 0.065 | 0.687 | 0.201 | 0.208 |
 | CTLA4 | 0.702 | *** | 0.006 | 0.971 | 0.137 | 0.391 | 0.021 | 0.895 | 0.095 | 0.553 | 0.180 | 0.261 | 0.030 | 0.854 |
 | LAG3 | 0.560 | *** | 0.041 | 0.797 | 0.037 | 0.819 | 0.078 | 0.630 | 0.078 | 0.629 | 0.315 | 0.045 | 0.198 | 0.214 |
 | TIM-3 (HAVCR2) | 0.387 | * | 0.340 | * | 0.061 | 0.704 | 0.187 | 0.242 | 0.288 | 0.068 | 0.551 | *** | 0.082 | 0.609 |
 | GZMB | 0.243 | 0.122 | 0.136 | 0.396 | 0.084 | 0.600 | 0.125 | 0.437 | 0.100 | 0.533 | 0.459 | ** | 0.216 | 0.174 |
 | PDL1 (CD274) | 0.365 | * | 0.636 | *** | 0.383 | * | 0.372 | * | 0.606 | *** | 0.864 | *** | 0.156 | 0.330 |
 | TIGIT | 0.432 | ** | 0.161 | 0.314 | 0.042 | 0.796 | 0.071 | 0.661 | 0.141 | 0.380 | 0.198 | 0.215 | 0.153 | 0.341 |
 | CD112 (PVRL2) | 0.432 | ** | 0.037 | 0.818 | 0.115 | 0.476 | 0.202 | 0.205 | 0.045 | 0.782 | 0.263 | 0.097 | 0.171 | 0.286 |
 | CD155 (PVR) | 0.436 | *** | 0.363 | * | 0.139 | 0.384 | 0.174 | 0.277 | 0.363 | * | 0.626 | *** | 0.120 | 0.454 |
 | CD113 (PVRL3) | 0.508 | *** | 0.655 | *** | 0.424 | ** | 0.479 | ** | 0.613 | *** | 0.674 | *** | 0.486 | ** |
 | CD226 (DNAM-1) | 0.662 | *** | 0.619 | *** | 0.260 | 0.101 | 0.440 | ** | 0.612 | *** | 0.601 | *** | 0.314 | * |
 | CD96 | 0.704 | *** | 0.407 | ** | 0.145 | 0.365 | 0.223 | 0.160 | 0.306 | * | 0.440 | ** | 0.102 | 0.525 |