Fig. 4

Proteins in plasma and serum are associated with overall survival. A The 10 most important plasma proteins for survival outcome were extracted from the plasma cohort RSF model (VIMP: Variable Importance). B Forest plot from the Swedish training data for MMP12, stage, grade, age and sex. High MMP12 levels are significantly associated with poor overall survival (hazard ratio > 1, p < 0.05). C Kaplan–Meier Survival Estimates curves from two urothelial cancer patient cohorts based on high or low MMP12 protein levels. Cut-off levels were calculated by maximally selected rank statistics. D RSF model predicted overall survival probability at different MMP12 NPX levels after 6 months, 1 year and 5 years