Fig. 2

Immune-oncology protein marker profiles in plasma and urine of UBC patients. Unsupervised hierarchical clustering of patients based on (A) plasma and (B) urine protein NPX levels with corresponding clinical information presented above. Uniform manifold approximation and projection analysis of the overall protein marker levels in (C) plasma and (D) urine with Ta-T1 (NMIBC) and T2-T4 (MIBC) indicated in purple and orange, respectively. Circles represent low-grade and triangles high-grade tumours. E The correlation matrix for the 12 proteins significantly correlated between plasma and urine in paired samples (Spearman's rank-order correlation p < 0.05, p-adj < 0.05). Yellow represents a positive correlation and blue negative correlation with the size of the circle proportional to its R-value