Fig. 3

Variant numbers of the individual mitochondrial genes, including non-coding regions, in the colorectal cancer patients. Mean ± standard error of the variant number (upper panels) in each mitochondrial gene and the non-coding regions (D-loop, rRNA, tRNA) and the variant mutation rate per kilobase (kb; lower panels) are shown for each gene, as analyzed in whole blood (WB), peripheral blood mononuclear cells (PBMC), plasma extracellular vesicles (EV), and formalin-fixed paraffin-embedded (FFPE) or fresh-frozen (FF) tumor specimens from (A) rectal cancer patients (n = 8) and (B) colon cancer patients (n = 8). The mitochondrial complex of which each gene encodes a protein subunit for, is shown at the bottom