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Table 4 Association between carriage of hemoglobinopathy genes and EBV acquisition

From: Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya

  

EBV status < 6 months

EBV status ≥ 6-12months

Gene mutation type

n

OR

95% CI

P-value

OR

95% CI

P-value

α- thalassemia

αα/αα

46

Ref

-

-

Ref

-

-

-α3.7/αα

34

1.824

0.511–6.512

0.354

0.681

0.256–1.812

0.442

Sickle cell Status

Hb AA

62

Ref

-

-

Ref

-

-

Hb AS

17

0.897

0.217–3.708

0.881

0.513

0.143–1.836

0.305

G6PD Group A1

871G > A/1024C > T-Negative

10

Ref

-

-

Ref

-

-

871G > A/1024C > T-Positive

71

2.614

0.578–11.820

0.212

0.640

0.079–5.205

0.677

G6PD group A2

487G > A/592C > T-Negative

4

Ref

-

-

Ref

-

-

487G > A/592C > T-Positive

77

0.000

0.000

0.999

0.948

0.240–3.755

0.940

G6PD group B

1360C > T /1388G > A-Negative

15

Ref

-

-

Ref

-

-

1360C > T /1388G > A-Positive

66

0.321

0.038–2.686

0.295

1.221

0.325–4.592

0.768

G6PD African A-

B

6

Ref

-

-

Ref

-

-

A-

19

xx

xx

1.000

0.000

0.000

0.235

A

55

xx

xx

0.999

0.278

0.030–2.544

0.257

B and A

61

Ref

-

-

Ref

  

A-

19

0.281

0.081–0.978

0.046

0.223

0.153–1.549

0.487

MSP-2

FC27 Negative

50

Ref

-

-

Ref

-

-

FC27 Positive

20

0.922

0.213–3.990

0.914

0.780

0.256–2.373

0.662

3D7 Negative

29

Ref

-

-

Ref

-

-

3D7 Positive

41

0.933

0.238–3.656

0.921

0.549

0.201–1.496

0.241

  1. G6PD: [Group A1(Viangchan 871G > A /Chinese 1024 C > T), Group A2 (Mahidol 487G > A/Coimbra 592 C > T), Group B (Union 1360 C > T / Kaiping 1388G > A)]: SCT; Sickle cell trait (Hb AS), Hb AA; Sickle cell normal: Alpha thalassemia (αα/αα, -α3.7/αα): B; Wild type, A-; (202 C > T/376T > A), A;(376T > A). xx; small sample size. Data are presented as odds ratios. OR Odds ratio: CI; Confidence interval
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BMC Cancer

ISSN: 1471-2407

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