| | ABSI (per one SD increase) | | HI (per one SD increase) | | BMI (per one SD increase) | |
---|
| Cases | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p |
---|
Overall | 9011 | 0.984 (0.961–1.007) | 0.162 | 1.013 (0.990–1.036) | 0.276 | 1.074 (1.049–1.098) | < 0.001 |
MP baseline
| | | | | | | |
Pre-MP | 2178 | 0.988 (0.941–1.038) | 0.643 | 1.028 (0.982–1.075) | 0.239 | 0.980 (0.932–1.030) | 0.422 |
Post-MP | 5268 | 0.971 (0.942-1.000) | 0.051 | 1.011 (0.981–1.041) | 0.490 | 1.117 (1.085–1.150) | < 0.001 |
p heterogeneity | | 0.535 | | 0.543 | | < 0.001 | |
Age diagnosis
| | | | | | | |
<55 years | 1968 | 1.006 (0.956–1.059) | 0.817 | 1.026 (0.979–1.076) | 0.285 | 0.966 (0.917–1.019) | 0.206 |
≥55 years | 7043 | 0.976 (0.951–1.002) | 0.067 | 1.006 (0.981–1.032) | 0.630 | 1.104 (1.076–1.132) | < 0.001 |
p heterogeneity | | 0.299 | | 0.476 | | < 0.001 | |
ERPR status
| | | | | | | |
ER + PR+ | 3101 | 0.971 (0.933–1.010) | 0.141 | 1.016 (0.978–1.056) | 0.409 | 1.122 (1.080–1.165) | < 0.001 |
ER + PR- | 726 | 0.894 (0.822–0.971) | 0.008 | 0.981 (0.905–1.063) | 0.644 | 0.998 (0.917–1.086) | 0.956 |
ER-PR- | 759 | 0.906 (0.835–0.983) | 0.018 | 1.028 (0.951–1.112) | 0.487 | 0.996 (0.919–1.081) | 0.933 |
p heterogeneity | | 0.108 | | 0.682 | | 0.004 | |
ER+/-PR- | 1485 | 0.900 (0.849–0.954) | < 0.001 | 1.006 (0.951–1.064) | 0.842 | 0.997 (0.940–1.057) | 0.924 |
p ER+/−PR− vs. ER+PR+ | | 0.037 | | 0.763 | | < 0.001 | |
HER2 status
| | | | | | | |
ER + PR + HER2+ | 288 | 1.042 (0.918–1.183) | 0.526 | 0.972 (0.860–1.098) | 0.647 | 1.206 (1.073–1.356) | 0.002 |
ER + PR + HER2- | 1690 | 0.981 (0.929–1.035) | 0.474 | 1.016 (0.965–1.071) | 0.542 | 1.148 (1.091–1.207) | < 0.001 |
p heterogeneity | | 0.390 | | 0.511 | | 0.449 | |
ER+/-PR-HER2+ | 298 | 0.934 (0.822–1.062) | 0.297 | 0.970 (0.858–1.096) | 0.624 | 1.045 (0.921–1.185) | 0.493 |
ER+/-PR-HER2- | 626 | 0.904 (0.826–0.989) | 0.027 | 1.017 (0.932–1.109) | 0.703 | 1.013 (0.926–1.108) | 0.778 |
p heterogeneity | | 0.680 | | 0.536 | | 0.693 | |
TNBC | 314 | 0.927 (0.817–1.051) | 0.238 | 1.046 (0.925–1.182) | 0.473 | 0.993 (0.874–1.127) | 0.908 |
- ABSI – a body shape index; BMI – body mass index; CI – confidence interval; ER+/- – oestrogen receptor status; HER2+/- – human epidermal receptor 2 status; HI – hip index; HR – hazard ratio; p-value – from Wald test for the individual term; Pre-MP – pre-menopausal at baseline (the day of the anthropometric assessment); Post-MP – post-menopausal at baseline; PR+/- – progesterone receptor status; SD – standard deviation; TNBC – triple-negative breast cancer (ER-PR-HER2- subtype); HR (95% CI) (per one SD increase) were derived from Cox proportional hazards models, including ABSI, HI, and BMI on a continuous scale (z-scores, value minus mean (72.939 for ABSI; 64.806 for HI; 25.304 for BMI), divided by SD (5.070 for ABSI; 2.717 for HI; 4.464 for BMI)) as exposures, stratified by age at the anthropometric assessment, country, and categories of menopausal status and, for post-menopausal women, age at menopause (pre-menopausal, peri-menopausal, menopause at < 46 years, menopause at 46 to < 52 years, menopause at ≥ 52 years, menopause at unknown age), and adjusted for height (continuous), smoking status and intensity (never smoker, former quit ≥ 15 years, former quit < 15 years, current ≤ 10 cigarettes/day, current > 10 cigarettes/day), alcohol consumption (none, < 4 g/day, 4 to < 16 g/day, ≥ 16 g/day), physical activity (inactive, moderately inactive, moderately active, active), education (primary/none, technical, secondary, university/longer), hormone replacement therapy use (never, former, current, missing), oral contraceptives use (never, former, current), age at the first period (continuous), parity with age at first live birth (nulliparous, one at < 25 years, one at ≥ 25 years, two at < 25 years, two at ≥ 25 years, ≥ 3 at < 25 years, ≥ 3 at ≥ 25 years, missing), breastfeeding with duration (never, < 6 months, ≥ 6 months, missing), energy intake (log-transformed continuous); pheterogeneity and pER+/−PR− vs. ER+PR+ were derived with the data augmentation method of Lunn and McNeil [21]