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Table 1 Anthropometric characteristics and breast cancer cases according to ABSI quintiles

From: A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Characteristics

ABSI-Q1

ABSI-Q2

ABSI-Q3

ABSI-Q4

ABSI-Q5

Cohort size: n

43,655

43,655

43,656

43,655

43,655

Cases overall: n

1736

1879

1761

1835

1800

ER + PR + subtypes a

498 (64.8)

593 (63.4)

633 (65.5)

710 (69.8)

667 (66.3) ^

ER + PR- subtypes a

114 (14.8)

163 (17.4)

154 (15.9)

145 (14.3)

150 (14.9)

ER-PR- subtypes a

135 (17.6)

163 (17.4)

157 (16.3)

141 (13.9)

163 (16.2)

ERPR unknown b

968 (55.8)

944 (50.2)

795 (45.1)

818 (44.6)

794 (44.1) #

HER2 + subtypes a

99 (19.9)

132 (22.6)

118 (19.8)

120 (18.3)

131 (21.1) ^

HER2- subtypes a

398 (80.1)

452 (77.4)

477 (80.2)

534 (81.7)

491 (78.9)

HER2 unknown b

1239 (71.4)

1295 (68.9)

1166 (66.2)

1181 (64.4)

1178 (65.4) #

Follow-up: years c

13.4 (4.6)

12.9 (4.6)

12.7 (4.6)

12.7 (4.6)

12.7 (4.5) #

Age at diagnosis: years c

60.3 (9.5)

61.5 (9.0)

62.0 (8.9)

62.8 (9.1)

64.3 (8.6) #

Age at baseline: years c

47.2 (11.3)

50.2 (10.3)

51.9 (9.8)

53.3 (9.4)

55.1 (9.4) #

Anthropometry

     

Height: cm c

162.8 (6.4)

162.3 (6.5)

162.0 (6.6)

161.6 (6.8)

161.1 (7.1) #

Weight: kg c

65.5 (11.0)

64.6 (10.8)

65.5 (11.5)

66.9 (12.1)

68.9 (12.7) #

BMI: kg/m2 c

24.8 (4.1)

24.5 (4.1)

25.0 (4.4)

25.6 (4.6)

26.6 (4.8) #

WC: cm c

71.5 (7.4)

75.3 (8.0)

78.8 (8.8)

82.9 (9.6)

90.3 (11.1) #

HC: cm c

98.6 (8.4)

99.3 (8.4)

100.3 (8.8)

101.6 (9.1)

103.6 (9.8) #

ABSI c

66.2 (2.4)

70.3 (0.8)

72.7 (0.7)

75.3 (0.8)

80.2 (3.3) #

HI c

63.9 (3.0)

64.7 (2.5)

65.0 (2.4)

65.1 (2.4)

65.3 (3.0) #

Lifestyle

     

Never smoker d

24,479 (56.1)

23,674 (54.2)

23,792 (54.5)

24,000 (55.0)

24,227 (55.5) #

Alcohol none d

4246 (9.7)

5589 (12.8)

6737 (15.4)

7682 (17.6)

9488 (21.7) #

Physically inactive d

7325 (16.8)

8435 (19.3)

9551 (21.9)

11,368 (26.0)

14,003 (32.1) #

Education primary d

7672 (17.6)

11,145 (25.5)

13,231 (30.3)

15,983 (36.6)

19,255 (44.1) #

Reproductive

     

Age at first period c

12.9 (1.5)

13.0 (1.6)

13.1 (1.6)

13.1 (1.6)

13.2 (1.6) #

Age at menopause c

48.5 (5.2)

48.7 (4.9)

48.7 (4.9)

48.7 (4.9)

48.5 (5.1) ^

Post-menopausal d

15,956 (36.6)

19,403 (44.4)

21,986 (50.4)

24,533 (56.2)

28,176 (64.5) #

Nulliparous d

11,069 (25.4)

7697 (17.6)

6448 (14.8)

5657 (13.0)

5676 (13.0) #

Breastfeeding ≥ 6 mo d

13,397 (30.7)

14,649 (33.6)

15,236 (34.9)

15,687 (35.9)

16,475 (37.7) #

OC never d

12,818 (29.4)

15,056 (34.5)

16,833 (38.6)

18,843 (43.2)

21,770 (49.9) #

HRT never d

30,300 (69.4)

28,769 (65.9)

28,866 (66.1)

29,247 (67.0)

30,280 (69.4) #

  1. ABSI – a body shape index; BMI – body mass index; ER+/- – oestrogen receptor status; HC – hip circumference; HER2+/- – human epidermal receptor 2 status; HI – hip index; n– number of women or cases; PR+/- – progesterone receptor status; Q1-Q5 – study-specific quintile categories for ABSI (cut-offs: 68.843, 71.525, 73.919, 76.884); WC – waist circumference; a – number (percent form cases with available ERPR status (for ERPR) or with available ERPRHER2 status (for HER2) per ABSI quintile); b – number (percent form total cases per ABSI quintile); c – mean (standard deviation); d – number (percent form total women per ABSI quintile); p-values: ^ ≥0.05; * <0.05; # <0.0001 from ANOVA test for continuous variables and χ2 test for categorical variables, comparing quintile categories and, for each categorical variable, including all categories shown in Supplementary Table S1
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BMC Cancer

ISSN: 1471-2407

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