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Table 2 Summary of meta-analysis results for case–control/cohort studies (n=42 studies)

From: Association of reproductive risk factors and breast cancer molecular subtypes: a systematic review and meta-analysis

Reproductive factors

Contrast

Luminal A/ ER + , PR + , HER-

Luminal B/ ER + , PR + , HER + 

HER2-overexpressing/ER-, PR-, HER + 

Triple Negative/ basal-like/ER-, PR-, HER-

Age at menarche (n = 29)

Later vs. earlier

S-

NO

NO

S-

Age at menopause (n = 13)

Later vs. earlier

S + 

S + 

S + 

NS + 

Menopausal status (n = 7)

Post vs. pre/peri

S-

S-

NS + 

NS-

Age at first birth (n = 28)

Nulliparous/later vs. earlier age at FB

S + 

S + 

S + 

NS + 

Parity (n = 29)

Higher parity vs. low/nulliparity

S-

S-

NS-

NS + 

Breastfeeding (n = 30)

Ever /longer vs. never/shorter

S-

S-

S-

S-

OC use (n = 15)

Ever/longer vs. never/shorter

NS + 

NS + 

NS + 

S + 

HRT (n = 13)

Ever/longer vs. never/shorter

S + 

S + 

NS + 

NS + 

  1. Abbreviations: S- Significant lower risk, S+ Significant higher risk, NS+ Non-significant higher risk, NS- Non-significant lower risk, NO No difference (0.95 < RR < 1.05 and NS), FB First birth, OC Oral contraceptive
  2. HRT Hormone replacement therapy, HER2 Human epidermal growth factor receptor 2