Table 1 Association of risk markers with main clinicopathological features

Variable

n (%)

P53

Ki-67

TPS

CPS

CD8

Wildtype

Mutant

p-value

Low

High

p-value

< 1%

≥ 1%

p-value

< 1

≥ 1

p-value

Low

High

p-value

Age

< 67 yrs

34 (50.3)

19

15

0.916

18

16

0.184

15

19

0.555

6

28

0.956

9

25

0.481

≥ 67 yrs

35 (50.7)

20

15

24

11

13

22

6

29

12

23

FIGO Stage

I

53 (76.8)

31

22

0.548

32

21

0.879

24

29

0.148

12

41

0.055

20

33

0.027

II - III

16 (23.2)

8

8

10

6

4

12

0

16

1

15

Grade

1

45 (65.2)

26

19

0.773

31

14

0.062

19

26

0.704

9

36

0.521

17

28

0.070

2–3

24 (34.8)

13

11

11

13

9

15

3

21

4

20

LMN

Negative

63 (91.3)

36

27

1.000

39

24

0.672

26

37

1.000

12

51

0.581

21

42

0.167

Positive

6 (8.7)

3

3

3

3

2

4

0

6

0

6

HPV status

Negative

51 (73.9)

23

28

0.001

39

12

< 0.001

19

32

0.344

9

42

1.000

13

38

0.133

Positive

18 (26.1)

16

2

3

15

9

9

3

15

8

10

P53

Wildtype

39 (56.5)

-

-

-

24

15

0.897

19

20

0.117

6

33

0.616

16

23

0.029

Mutant

30 (43.5)

-

-

18

12

9

21

6

24

5

25

Ki-67

Low

42 (60.9)

24

18

0.897

-

-

-

17

25

0.983

6

36

0.518

14

28

0.514

High

27 (39.1)

15

12

-

-

11

16

6

21

7

20

TPS

< 1%

28 (40.6)

19

9

0.117

17

11

0.983

-

-

-

6

22

0.527

12

16

0.064

≥ 1%

41 (59.4)

20

21

25

16

-

-

6

35

9

32

CPS

< 1

12 (17.4)

6

6

0.616

6

6

0.518

6

6

0.527

-

-

-

7

5

0.036

≥ 1

57 (82.6)

33

24

36

21

22

35

-

-

-

14

43

CD8

Low

21 (30.4)

16

5

0.029

14

7

0.514

12

9

0.064

7

14

0.036

-

-

-

High

48 (69.6)

23

25

28

20

16

32

5

43

-

-