Table 2 Overall survival of osteosarcoma patients in different variables
Variables | 3-year OSR | 5-year OSR | AOS (95%CI) months | χ2 | P-value |
|---|---|---|---|---|---|
Age (year) | |||||
≤ 18 | 72.9% | 59.6% | 91.9 ± 7.6 (77.0–106.8) | 1.989 | 0.370 |
19–40 | 83.3% | 80.6% | 113.1 ± 7.7 (98.0–128.1) | ||
≥ 41 | 73.6% | NA | 100.4 ± 12.9 (75.2–125.6) | ||
Gender | |||||
Male | 68.8% | 64.3% | 96.7 ± 7.6 (81.8–111.6) | 2.633 | 0.105 |
Female | 87.6% | 76.9% | 108.1 ± 6.8 (94.8–121.5) | ||
Tumor site | |||||
Upper limb | 66.7% | NA | 85.7 ± 13.0 (60.4–111.1) | 6.522 | 0.038 |
Lower limb | 80.0% | 71.8% | 106.9 ± 5.7 (95.7–118.1) | ||
Spine-pelvis | NA | NA | 26.4 ± 5.5 (15.7–37.2) | ||
Stage T | |||||
T1 | 84.0% | 69.4% | 98.2 ± 8.3 (82.0–114.5) | 1.683 | 0.641 |
T2 | 73.5% | NA | 98.3 ± 6.4 (85.8–110.9) | ||
T3 | NA | NA | 16.0 ± 3.3 (9.6–22.4) | ||
Unknown | NA | NA | 110.5 ± 29.0 (53.6–167.4) | ||
Stage N | |||||
N0 | 78.5% | 69.5% | 103.4 ± 6.1 (91.5–115.3) | 12.595 | 0.002 |
N1 | 0 | NA | 19.8 ± 6.9 (6.2–33.3) | ||
Unknown | 79.8% | 75.8% | 106.7 ± 10.4 (86.4–127.0) | ||
Bone Mets | |||||
No | 89.7% | 79.9% | 116.0 ± 5.5 (105.3–126.7) | 12.890 | < 0.001 |
Yes | 68.3% | 49.1% | 68.8 ± 10.0 (49.2–88.3) | ||
Lung Mets | |||||
No | NA | NA | 139.2 ± 2.8 (133.7–144.6) | 89.029 | < 0.001 |
SLM | 41.7% | 0 | 33.3 ± 12.6 (8.6–57.9) | ||
MLM | 40.5% | 22.8% | 45.8 ± 7.4 (31.3–60.3) | ||
Surgery | |||||
No | NA | NA | 57.4 ± 16.6 (24.9–89.9) | 9.748 | 0.021 |
Salvage | 75.6% | 69.6% | 101.6 ± 6.7 (88.4–114.7) | ||
Amputation | 80.7% | 70.2% | 101.2 ± 9.1 (83.5–119.0) | ||
Unknown | NA | NA | 78.3 ± 5.5 (67.6–89.0) | ||
Chemotherapy | |||||
No | NA | NA | NA | 1.692 | 0.429 |
Yes | 75.7% | 68.0% | NA | ||
Unknown | NA | NA | NA | ||
Necrosis | |||||
< 90% | 69.3% | 51.5% | 80.0 ± 8.3 (63.6–96.4) | 10.297 | 0.006 |
≥ 90% | NA | NA | 130.0 ± 4.9 (120.5–139.6) | ||
Unknown | 76.2% | 72.6% | 108.7 ± 7.6 (93.8–123.7) | ||
Ki-67 | |||||
< 50% | 77.0% | NA | 92.5 ± 9.7 (73.5–111.5) | 2.399 | 0.301 |
≥ 50% | NA | NA | 98.8 ± 9.7 (79.8–117.8) | ||
Unknown | 74.5% | NA | 99.9 ± 6.4 (87.3–112.6) | ||
LDH | |||||
Normal | 79.7% | 70.1% | 106.1 ± 6.1 (94.2–118.1) | 0.554 | 0.456 |
Elevated | 70.2% | NA | 97.8 ± 10.9 (76.5–119.1) | ||
ALP | |||||
Normal | 84.9% | 78.7% | 113.8 ± 7.9 (98.3–129.3) | 8.150 | 0.017 |
Within one time | 80.9% | NA | 112.7 ± 8.3 (96.5–129.0) | ||
More than two times | 64.0% | 51.8% | 75.0 ± 9.1 (57.1–92.8) | ||