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Table 2 Overlap of fusions between the three cohorts as well as their occurrence in Mitelman DB

From: Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer

Fusion

FFPE_Bx

FF_RP

TCGA_PRAD

Known

ERG(30,742),NCRNA00114(46,499)::ERG

1

1

1

FALSE

AMACR::AMACR

1

1

1

FALSE

FSIP1::RP11-624L4.1

1

1

1

FALSE

MBTPS2(33,120),LL0XNC01-39B3.1(20,917)::SMS

1

1

1

FALSE

AMBRA1::CKAP5

1

1

0

FALSE

THBS1::RP11-624L4.1

1

1

0

FALSE

LINC00506(49,329),MIR4795(19,791)::CHMP2B

1

1

0

FALSE

RP11-159H20.3(25,945),FOXB2(602)::PRUNE2

1

1

0

FALSE

RP11-597A11.11::RP11-597A11.1

1

1

0

FALSE

AC004921.2(27,972),PTPN12(47,164)::GSAP

1

1

0

FALSE

RP11-356O9.1::ETV1

1

0

1

FALSE

PTEN::RP11-380G5.4(8171),RP11-129G17.2(201,135)

1

0

1

FALSE

PTEN::RNLS

1

0

1

FALSE

MAPKAPK5::ACAD10

1

0

1

FALSE

ACPP::CPNE4

1

0

1

FALSE

CTC-340A15.2::CTC-535M15.2

1

0

1

FALSE

PLPP1::SKIV2L2

1

0

1

FALSE

SCHLAP1::UBE2E3

1

0

1

FALSE

RP11-17A19.1::KCTD1

1

0

1

FALSE

ZFHX3::AC004158.2

1

0

1

FALSE

RP11-356O9.1::MIPOL1

0

1

1

FALSE

TTC6::SLC25A21

0

1

1

FALSE

RP11-599B13.3::ETV1

0

1

1

FALSE

C1QTNF3-AMACR::AMACR

0

1

1

FALSE

RP11-492D6.3::RP11-810K23.8(24,509),RP11-810K23.6(7644)

0

1

1

FALSE

SLC45A3::ELK4

1

1

1

TRUE

TMPRSS2::ERG

1

1

1

TRUE

TMPRSS2::ETV4

1

1

1

TRUE

TTC6::MIPOL1

1

1

1

TRUE

SLC45A3::ERG

1

1

1

TRUE

ERG::TMPRSS2

1

0

1

TRUE

PMEPA1::ETV4

1

0

1

TRUE

SLC45A3::ETV1

1

0

1

TRUE

IQSEC1::SCCPDH

1

0

1

TRUE

GPATCH8::PYY

1

0

1

TRUE

PDZRN3::EIF4E3

0

1

1

TRUE

  1. The rows show 36 gene fusions found in at least two cohorts. Columns 2–4 show the detection status of the fusion per cohort, where 1 means fusion can be detected and 0 means fusion cannot be detected. Column 5 states whether the fusion can be found in the Mitelman DB (TRUE) or not (FALSE). The table is gradually sorted by prominence according to the Mitelman DB (column 5) and the sum of cohorts in which a fusion can be found, as well as their rediscovery in FFPE_Bx