Table 5 Univariable and multivariable analysis for overall survival

Gender (Female)

1.474 (0.852, 2.550)

0.165

Age(≥65yr)

1.402 (0.816, 2.406)

0.221

Tumor location

0.008

0.032

 Lower third

1

1

 Middle third

1.586 (0.898, 2.800)

0.112

1.756 (0.915, 3.369)

0.091

 UGEJ

0.712 (0.314, 1.617)

0.417

0.437 (0.159, 1.198)

0.108

 Diffuse

3.232 (1.480, 7.055)

0.003

2.220 (0.881, 5.593)

0.091

Tumour size (≥5cm)

3.092 (1.684, 5.680)

<0.001

1.808 (0.812, 4.024)

0.147

ypT (3-4)

7.331 (2.659, 20.215)

<0.001

3.671 (0.995, 13.564)

0.051

ypN (2-3)

3.256 (1.969, 5.385)

<0.001

1.930 (0.709, 5.257)

0.198

ypTNM (III)

4.442 (2.456, 8.036)

<0.001

1.816 (0.854, 3.903)

0.126

Histological types

1.167 (0.716, 1.904)

0.535

Lauren classification

1.925 (1.178, 3.144)

0.009

1.576 (0.814, 3.054)

0.177

Degree of differentiation

2.733 (1.303, 5.731)

0.008

1.679 (0.682, 4.130)

0.259

Vascular or lymphatic invasion

1.901 (1.126, 3.210)

0.016

1.141 (0.571, 2.280)

0.708

Nerve invasion

1.256 (0.716, 2.206)

0.427

Mandard TRG (3-5)

2.861 (1.557, 5.260)

0.001

0.669 (0.297, 1.506)

0.332

CAF markers

 FAP (+)

1.843 (1.139, 2.983)

0.013

1.465 (0.652, 3.292)

0.356

 CD10 (+)

1.832 (1.053, 3.189)

0.032

0.920 (0.436, 1.944)

0.827

 GPR77 (+)

1.329 (0.657, 2.690)

0.429

0.697 (0.291, 1.669)

0.418

EMT markers

 N-cadherin (+)

2.158 (1.334, 3.490)

0.002

1.908 (1.057, 3.443)

0.032

 Snail1 (+)

1.735 (1.047, 2.876)

0.033

2.081 (1.082, 4.004)

0.028

 Twist1 (+)

1.335 (0.827, 2.157)

0.237

0.634 (0.357, 1.128)

0.121

CSC markers

 ALDH1 (+)

1.148 (0.685, 1.925)

0.601

0.681 (0.367, 1.265)

0.224

 LGR5 (+)

1.473 (0.899, 2.413)

0.124

1.685 (0.916, 3.100)

0.093

 CD44 (+)

1.095 (677, 1.772)

0.710

0.627 (0.334, 1.179)

0.147