Table 4 Univariable and multivariable analysis of the pathological response

Gender (Female)

0.721 (0.353, 1.474)

0.370

Age(≥65yr)

0.760 (0.355, 1.626)

0.479

Tumor location

0.444

 Lower third

1

 Middle third

0.892 (0.344, 2.313)

0.814

 UGEJ

1.450 (0.618, 3.401)

0.393

 Diffuse

2.526 (0.457, 13.964)

0.288

Tumour size (≥5cm)

6.052 (3.052, 12.101)

<0.001

4.397 (1.190, 16.249)

0.026

ypT(3-4)

30.600 (10.840, 86.379)

<0.001

6.260 (1.124, 34.867)

0.036

ypN

<0.001

0.320

 0

1

1

 1

1.429 (0.600, 3.404)

0.420

0.454 (0.044, 4.663)

0.506

 2

6.452 (2.012, 20.690)

0.002

1.428 (0.065, 31.308)

0.821

 3

4.473 (1.861, 10.753)

<0.001

0.228 (0.012, 4.397)

0.327

ypTNM (III)

6.364 (3.147, 12.869)

<0.001

1.891 (0.139, 25.676)

0.632

Histological types

2.275 (1.135, 4.559)

0.020

2.231 (0.598, 8.317)

0.232

Lauren classification

1.663 (0.874, 3.162)

0.121

Degree of differentiation

4.336 (1.986, 9.599)

<0.001

1.718 (0.399, 7.398)

0.468

Vascular or lymphatic invasion

3.575 (1.400, 9.127)

0.008

3.104 (0.518, 18.588)

0.215

Nerve invasion

4.007 (1.466, 10.956)

0.007

1.838 (0.351, 9.622)

0.471

CAF markers

 FAP (+)

24.826 (7.326, 84.128)

<0.001

16.905 (2.468,115.810)

0.004

 CD10 (+)

20.602 (2.731, 155.415)

0.003

19.022 (0.506,715.246)

0.111

 GPR77 (+)

12.258 (1.601, 93.825)

0.016

3.365 (0.131, 86.710)

0.464

EMT markers

 N-cadherin (+)

2.847 (1.386, 5.849)

0.004

0.512 (0.125, 2.093)

0.351

 Snail1 (+)

2.983 (1.329, 6.697)

0.008

0.521 (0.108, 2.510)

0.416

 Twist1 (+)

10.174 (4.404, 23.506)

<0.001

14.238 (3.020, 67.130)

0.001

CSC markers

 ALDH1 (+)

2.024 (1.052,3.892)

0.035

0.844 (0.237, 3.005)

0.794

 LGR5 (+)

2.796 (1.456,5.368)

0.002

1.861 (0.404, 8.583)

0.426

 CD44 (+)

2.324 (1.200, 4.501)

0.012

0.827 (0.205, 3.333)

0.790