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Table 4 Differences in the expression of TC PD-L1 and LAG-3 among the molecular subtypes of breast cancer

From: Characterization of immune checkpoints expression and lymphocyte densities of iranian breast cancer patients; the co-expression status and clinicopathological associates

 

Negative

Positive

OR (95% CI)

P-value

TC PD-L1

268

29

 

Luminal A

103 (38.4)

3 (10.3)

0.18 (0.03, 0.63)

0.027

Luminal B

104 (38.8)

11 (37.9)

0.95 (0.39, 2.23)

0.90

HER2-enriched

25 (9.3)

7 (24.1)

3.10 (1.12, 8.4)

0.014

TNBC

36 (13.4)

8 (27.6)

2.43 (1.02, 6.2)

0.043

LAG-3

108

172

 

Luminal A

52 (48.1)

51 (29.7)

0.49 (0.29, 0.83)

0.047

Luminal B

30 (27.8)

77 (44.8)

1.97 (1.16, 3.39)

0.007

HER2-enriched

11 (10.2)

18 (10.5)

0.47 (0.17, 1.28)

0.97

TNBC

15 (13.9)

26 (15.1)

0.30 (0.11, 0.77)

0.87

  1. PD-L1, programmed death-ligand 1; TC, tumoral cells; OR, odds ratio; CI, confidence interval; HER2, human epidermal growth factor receptor 2; LAG-3, lymphocyte activation gene-3; TNBC, triple-negative breast cancer