Fig. 1

Uterine Leiomyosarcoma (uLMS) (A-B): H&E shows spindle-shaped cells in fascicles with atypical hyperchromatic nuclei at 40x (A). The tumor cells stain diffuse and strong for immunohistochemical (IHC) stain h-caldesmon (B). Adenosarcoma(AS) (C-E): 10x: Characteristic leaf-like architecture of benign glands with surrounding condensed peri glandular stroma (C), 40x: Benign glandular epithelium and malignant stroma with cytologic atypia and mitosis (inset) (D), The glandular epithelium stains positive for IHC stain Cytokeratin AE1/AE3 (E). Low-grade endometrial stromal sarcoma (LGESS) (F-K): 10x: the lesion shows a permeative tongue like the pattern of myometrial invasion (F). At 20 × view the tumor cells appear monotonous ovoid to spindle shape (G), High power at 40 × shows minimal cytological atypia with cells whorling around delicate blood vessels (H), Diffuse positivity for IHC stain CD10 (I), The cells are completely negative for IHC stain Cyclin D1 (J), IHC stain-ER diffuse and strong nuclear positive (K). High-grade endometrial stromal sarcoma (HGESS) (L-N): 20x: Nested growth of round cells with scant cytoplasm and lymphovascular invasion (arrow) (L), 40x: Cells with scant cytoplasm and nuclear atypia (M), IHC stain Cyclin D1 diffuse and strong positive in tumor cells (N)