Fig. 6

Construction and validation of ICDRM. A Univariate Cox analysis evaluates the predictive value of ICDRM in terms of OS. B Lasso-Cox analysis identified 5-genes most associated with OS in TCGA. C Risk scores distribution, survival status of each patient, and heatmap of prognostic 5-genes signature in TCGA. D Univariate and multivariate Cox analyses evaluate the independent prognostic value of ICDRM in TCGA. E, F Comparison of the mutation landscape between subpopulations with high and low-risk scores. G Kaplan–Meier analyses demonstrate the prognostic significance of ICDRM in the TCGA, ICGC, and GSE76427 datasets. H AUC of time-dependent ROC curves verified the predictive performance of ICDRM in TCGA, ICGC, and GSE76427 datasets